Dissecting self-renewal in stem cells with RNA interference

By N. Ivanova, Radu Dobrin, R. Lu, Iulia Kotenko, J. Levorse, C. DeCoste, Xenia L. Schafer, Y. Lun, Ihor R. Lemischka. Nature, 2006

1,056 citations recorded by the source corpus.

Subfields: Molecular Biology

View Paper: https://www.semanticscholar.org/paper/9179e7ef29c7c4722da31bd73c62e5379b3b792f

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Citations in the corpus

Long noncoding RNAs in mouse embryonic stem cell pluripotency and differentiation. (2008, background): “2002) and many have established functions in maintenance of pluripotency (Ivanova et al. 2006).”
How is pluripotency determined and maintained? (2007, background): “Knockdown of Tcl1 in mouse ES cells impairs self-renewal by inducing differentiation and/or repressing their proliferation (Ivanova et al., 2006; Matoba et al., 2006).”
Stochastic state transitions give rise to phenotypic equilibrium in populations of cancer cells. (2011, neutral): “Genes implicated in the self-renewal of embryonic stem cells, including EZH2, KLF5, KLF4, and SOX9 (Brambrink et al., 2008; Ivanova et al., 2006; Parisi et al., 2008), were significantly enriched in their expression in the CD44 hi CD24 neg EpCAM lo fraction (Figures 1C and 1D and Table S1).”
An extended transcriptional network for pluripotency of embryonic stem cells. (2008, background): “…transcription factors and delineation of a protein-protein interaction network highly enriched for factors involved in the control of pluripotency (Ivanova et al., 2006; Wang et al., 2006), and preliminary global target gene assessment for the initial core factors (Boyer et al., 2005; Loh et al.,…”
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells (2011, background): “…gene expression in ESCs undergoing RA-induced differentiation also identified Tet1 (D10Ertd17e) as one of 65 rapidly downregulated candidate genes (Ivanova et al., 2006); however, Tet1 was not characterized further in this study, because—as also observed in our hands—shRNA-mediated knockdown of…”
Pluripotency governed by Sox2 via regulation of Oct3/4 expression in mouse embryonic stem cells (2007, background): “In mouse ES cells, Nanog has been shown to block the differentiation of ES cells into extra-embryonic endoderm cells by unknown mechanism”
ChIP-Seq of transcription factors predicts absolute and differential gene expression in embryonic stem cells (2009, background): “The Affymetrix MOE430 AB array proﬁles of the RA induction and Esrrb RNAi knockdownseriesarefromIvanovaetal.”
A mesenchymal-to-epithelial transition initiates and is required for the nuclear reprogramming of mouse fibroblasts. (2010, background): “, 2001; Murray and Gridley, 2006) and its overexpression induces ESC differentiation (Ivanova et al., 2006).”
Senescence impairs successful reprogramming to pluripotent stem cells. (2009, background): “New regulators of pluripotency (such as Esrrb, Dax1, Sall4, Rex1, Stat3, among others) have been identified by shRNA knockdown screens (Ivanova et al., 2006), proteomics (Wang et al., 2006) and analysis of transcription factor binding sites and gene expression data (Zhou et al., 2007).”
Integration of external signaling pathways with the core transcriptional network in embryonic stem cells. (2008, methodology): “Next, we analyzed the expression level of the genes found in each class by using a published microarray data set for undifferentiated ES cells (Ivanova et al., 2006), and we found that the expression level is highest for genes in class II, followed by genes in class I and class III.”
Control of Embryonic Stem Cell State (2011, background): “…5 (Niwa et al., 1998); 6 (Ying et al., 2003); 7 (Beattie et al., 2005; James et al., 2005; Vallier et al., 2005), 8 (Cartwright et al., 2005); 9 (Ivanova et al., 2006; Zhang et al., 2008); 10 (Wu et al., 2006; Zhang et al., 2006); 11 (Han et al.; Ivanova et al., 2006; Niwa et al., 2009), 12…”