Inflammation in Diabetic Retinopathy
By Johnny Tang, T. Kern. Progress in retinal and eye research, 2011
1,084 citations recorded by the source corpus.
Diabetes causes a number of metabolic and physiologic abnormalities in the retina, but which of these abnormalities contribute to recognized features of diabetic retinopathy (DR) is less clear. Many of the molecular and physiologic abnormalities that have been found to develop in the retina in diabetes are consistent with inflammation. Moreover, a number of anti-inflammatory therapies have been found to significantly inhibit development of different aspects of DR in animal models. Herein, we review the inflammatory mediators and their relationship to early and late DR, and discuss the potential of anti-inflammatory approaches to inhibit development of different stages of the retinopathy. We focus primarily on information derived from in vivo studies, supplementing with information from in vitro studies were important.
Subfields: Clinical Biochemistry, Neurology, Ophthalmology
View Paper: https://www.semanticscholar.org/paper/8ff7b5d879ba7697a5b4e11ad4900e2450e98d78
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Citations in the corpus
- The Role of the Reactive Oxygen Species and Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and Other Pathologies of the Anterior and Posterior Eye Segments in Adults (2016, background): “The oxidative stress regulates expression of proinflammatory proteins [167, 168].”
- Taking aim at the extracellular matrix: CCN proteins as emerging therapeutic targets (2011, background): “Substantial evidence from recent studies supports the involvement of chronic inflammation in the pathogenesis of diabetic nephropathy and retinopath”
- Epidemiology of diabetic retinopathy, diabetic macular edema and related vision loss (2015, background): “The role of inflammation in DR and DME is therefore an area of extensive study, and has been reviewed previously [118].”