1α,25-Dihydroxyvitamin D3 Has a Direct Effect on Naive CD4+ T Cells to Enhance the Development of Th2 Cells1

By A. Boonstra, F. Barrat, C. Crain, V. Heath, H. Savelkoul, A. O’Garra. Journal of Immunology, 2001

915 citations recorded by the source corpus.

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

Vitamin D: modulator of the immune system. (2010, background): “Till date, the direct effects of 1,25(OH)2D3 on the emergence of Th2 cytokines are less clear: some studies show that 1,25(OH)2D3 favors the emergence of Th2 cells by upregulating the expression of Th2-specific transcription factors GATA-3 and c-maf and concomitant cytokines, including IL-4, whereas”
Vitamin D and Immune Function (2013, background): “In particular, treatment of T cells with calcitriol or analogs inhibits the secretion of proinflammatory Th1 (IL2, interferon-γ, tumor necrosis factor α), Th9 (IL9) and Th22 (IL22) cytokines [78–83], but promotes the production of more anti-inflammatory Th2 cytokines (IL3, IL4, IL5, IL10) [84].”
IL-33, an interleukin-1-like cytokine that signals via the IL-1 receptor-related protein ST2 and induces T helper type 2-associated cytokines. (2005, methodology): “In these highly polarized cells, we did not observe a further increase in the already high production of IL-4, although in vivo administration of IL-33 clearly induced IL-4 mRNA in multiple tissues.”
Vitamin D and cardiovascular disease. (2014, background): “regulated, and that of MMP-2 and MMP-9 is upregulated in cardiac muscle.(60) There is some clinical evidence that vitamin”