Non-transcriptional control of DNA replication by c-Myc

By D. Dominguez-Sola, C. Ying, C. Grandori, L. Ruggiero, Brenden Chen, Muyang Li, D. Galloway, W. Gu, J. Gautier, R. Dalla-Favera. Nature, 2007

681 citations recorded by the source corpus.

Subfields: Cell Biology, Molecular Biology, Oncology

View Paper: https://www.semanticscholar.org/paper/8fc5c4c3a3c568cb08824372a345c601a0262ac7

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

In Molecular Biology

In Oncology

Citations in the corpus

MYC on the Path to Cancer (2012, background): “Myc also appears to recruit DNA replication licensing factors to catalyze DNA replication, although whether its transcriptional function at replication origins is part-and-parcel of its DNA replication activity is not yet clear (Dominguez-Sola et al., 2007).”
Germinal centres: role in B-cell physiology and malignancy (2008, background): “, possibly caused by a direct non-transcriptional role of MYC in DNA replication, which was recently show”
Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation (2011, background): “Conversely, both NOTCH1 mutational activa tion and MYC deregulation often coexist with inactivation of the TP53 tumor suppressor gene, an event that is commonly observed in association with MYC activation in tumors, which may be selected to prevent the apoptotic effects and the re sponse to genomi”
Epigenetic reprogramming and induced pluripotency (2009, background): “A few pleiotropic functions have been suggested for cMyc, ranging from the control of initiation of DNA replication (Dominguez-Sola et al., 2007) to global effects on chromatin structure, especially on histone acetylation (Knoepfler, 2008), which could be important for providing the other…”
Mechanisms and pathways of growth failure in primordial dwarfism. (2011, background): “1996, 1998, 1999; Asano and Wharton 1999), while Myc has been reported to have a nontranscriptional regulative role, directly binding the preRC complex and modulating origin activity (Dominguez-Sola et al. 2007).”
Reflecting on 25 years with MYC (2008, background): “Interestingly, recent publications have re-awakened serious interest in understanding the role of MYC in DNA replicatio”
MYC activation is a hallmark of cancer initiation and maintenance. (2014, background): “MYC overexpression has been observed to enforce DNA replication and entry into S phase (Cerni et al. 1986; Mai et al. 1996; Felsher et al. 2000; Dominguez-Sola et al. 2007).”
Role of the murine reprogramming factors in the induction of pluripotency (2009, neutral): “In addition, c-Myc normally fulfills many other functions, for example in regulating DNA replication (Dominguez-Sola et al., 2007) and global histone acetylation (Knoepfler et al.”
Myc and cell cycle control. (2015, background): “Myc overexpression initiates premature origin firing and increases origin density, and leads to asymmetrical fork progression [201,202].”
Cancer-related inflammation, the seventh hallmark of cancer: links to genetic instability. (2009, background): “c-Myc induces DSB, as well as activated Ras [167], by production of ROS [168] (see above) and utilization of cryptic replication origins leading to aberrant and incomplete DNA synthesis [169].”
MYC, Metabolism, and Cancer. (2015, background): “In addition, MYC may have roles in initiation of DNA replication independent of its transcriptional activities, as it has been noted to localize to early sites of DNA replication and bind numerous components of the prereplicative complex (191).”
Myc's broad reach. (2008, background): “Finally, the recent demonstration that Myc can bind to and stimulate origins of DNA replication, independent of Myc transcriptional function (Dominguez-Sola et al. 2007), would suggest that many of the presumed nonproductive Myc-binding sites are replication origins.”