Analysis of the chronic lymphocytic leukemia coding genome: role of NOTCH1 mutational activation

By G. Fabbri, S. Rasi, D. Rossi, V. Trifonov, Hossein Khiabanian, Jing Ma, A. Grunn, Marco Fangazio, D. Capello, S. Monti and 18 more. Journal of Experimental Medicine, 2011

787 citations recorded by the source corpus.

Next generation sequencing and copy number analysis provide insights into the complexity of the CLL coding genome, and reveal an association between NOTCH1 mutational activation and poor prognosis.

Subfields: Genetics, Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/8bdd0f8a1f2c9c5e3969201a15ef365c6822728a

How researchers see this paper

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In Genetics

1. Chip Stewart
2. Stacey Gabriel
3. Eric S. Lander
4. Mark J. Daly

In Immunology

1. G. Getz
2. Catherine J. Wu
3. S. Shukla
4. Nir Hacohen
5. Nicholas McGranahan
6. Charles Swanton

In Oncology

1. Catherine J. Wu
2. Eric S. Lander
3. Nicholas McGranahan
4. Charles Swanton

Citations in the corpus

• Evolution and impact of subclonal mutations in chronic lymphocytic leukemia (2013, positive): “Our study thus uncovers patterns of clonal evolution in CLL, providing insights into its stepwise transformation, and links the presence of subclones with adverse clinical outcomes.”