The STATs of cancer — new molecular targets come of age
By Hua Yu, R. Jove. Nature Reviews. Cancer, 2004
2,373 citations recorded by the source corpus.
Subfields: Oncology, Pathology and Forensic Medicine
View Paper: https://www.semanticscholar.org/paper/8f224aed28ef3e6ae2d9685569a69f9d047999dc
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Citations in the corpus
- Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity (2005, background): “Stat3 regulates multiple genes crucial for tumor-cell survival and proliferatio”
- Triterpenoids and rexinoids as multifunctional agents for the prevention and treatment of cancer (2007, background): “STAT transcription factors are frequently constitutively activated in cancer”
- A human colonic commensal promotes colon tumorigenesis via activation of T helper type 17 T cell responses (2009, positive): “IL-6 induces the procarcinogenic Stat3 pathway and transcriptionally activates proliferative, antiapoptotic and proangiogenic genes involved in cancer growt”
- The tumour microenvironment as a target for chemoprevention (2007, background): “STATs are constitutively overexpressed in many cancers; their phosphorylation, which is required for transcriptional activity, is regulated by a set of kinases (JAKs), phosphatases and binding proteins, all of which are targets for drug developmen”
- A renaissance for SRC (2004, background): “STAT3 activation by v-Src has also been shown to contribute to other biological properties of cancer cells, including cell growth and survival, and tumour-cell immune evasio”
- Persistently-activated Stat3 maintains constitutive NF-κB activity in tumors (2009, positive): “, 1999), and it is commonly activated in cancer (Darnell, 2002; Yu and Jove, 2004) as well as in tumor-associated myeloid cells (Kortylewski et al.”
- Mechanisms and functional significance of tumour-induced dendritic-cell defects (2004, background): “Furthermore, STAT3 has been implicated in the regulation of expression of VEGF and in the SRC -mediated transformation of fibroblasts and haematopoietic cell lines (reviewed in Ref”