Mechanisms and functional significance of tumour-induced dendritic-cell defects

By D. Gabrilovich. Nature reviews. Immunology, 2004

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High expression of PD-L1 in lung cancer may contribute to poor prognosis and tumor cells immune escape through suppressing tumor infiltrating dendritic cells maturation (2011, background): “antigen-specific dendritic cells (DC) activation and immune function [ 8 ].”
Immune evasion in cancer: Mechanistic basis and therapeutic strategies. (2015, positive): “DCs retaining the immature phenotype are t olerogenic 198 as they do not present antigen in the proper context (with appropriate costimulati on to T cells 199 [46].”
Arginase-producing myeloid suppressor cells in renal cell carcinoma patients: a mechanism of tumor evasion. (2005, background): “It is likely that these represent a subpopulation of myeloid cells induced by tumor-derived factors as suggested by Gabrilovich (13).”
Dendritic cells as therapeutic vaccines against cancer (2005, background): “, as well as possibly protecting it from tumour-derived inhibitory factors (such as vascular endothelial growth factor or IL-10”
Myeloid-Derived Suppressor Cells: Linking Inflammation and Cancer (2009, background): “Their accumulation has been documented in most patients (15, 16) and mice (17) with cancer, where they are induced by various factors produced by tumor cells and/or by host cells in the tumor microenvironment (9, 18).”