Persistence of Mycobacterium tuberculosis in macrophages and mice requires the glyoxylate shunt enzyme isocitrate lyase

By J. Mckinney, K. H. Z. Bentrup, E. Muñoz-Elías, A. Miczak, Bing Chen, Wai-Tsing Chan, D. Swenson, J. Sacchettini, W. Jacobs, D. Russell. Nature, 2000

1,378 citations recorded by the source corpus.

Subfields: Epidemiology, Infectious Diseases, Surgery

View Paper: https://www.semanticscholar.org/paper/8f096aa3db77772dd99280cba3e3c568cf857278

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Epidemiology

1. M. Gengenbacher
2. Christopher M. Sassetti
3. Stefan H. E. Kaufmann
4. Paul D. Cotter
5. C. Hill
6. A. Pandey
7. I. Smith
8. Julian Parkhill

In Infectious Diseases

1. M. Gengenbacher
2. Stefan H. E. Kaufmann
3. Christopher M. Sassetti
4. Paul D. Cotter
5. C. Hill
6. A. Pandey
7. Gerald Fink
8. C. Nathan

In Surgery

1. Stefan H. E. Kaufmann
2. M. Gengenbacher
3. Paul D. Cotter
4. C. Hill
5. I. Smith
6. Christopher M. Sassetti

Citations in the corpus

• How can immunology contribute to the control of tuberculosis? (2001, background): “In vitro experiments indicate that mycobacteria switch to lipid catabolism and nitrate respiration to ensure their surviva”
• Who puts the tubercle in tuberculosis? (2007, background): “tuberculosis in macrophages that are exposed to activating cytokine”
• Mycobacterium tuberculosis Pathogenesis and Molecular Determinants of Virulence (2003, methodology): “It initially grows normally in mice but stops growing in lungs and is cleared at the time when cell-mediated immunity is initiated, a PER phenotype (188).”
• Transcriptional Adaptation of Mycobacterium tuberculosis within Macrophages (2003, background): “Icl was analyzed because it has been reported as specifically regulated in response to macrophage activation (21) but was strongly induced in activated and naive macrophages in the present array experiments.”
• High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism (2011, neutral): “A few genes that we found to contain very significant gaps in transposon coverage have been successfully deleted, and produce strains that grow normally under similar conditions to those used in our study [33,34,35,36,37,38].”
• Mycobacterial persistence requires the utilization of host cholesterol (2008, background): “tuberculosis, Icl1, leads to a chronic persistence defect that is very similar to the mce4 deletion (19).”
• Inhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program (2003, background): “tuberculosis express isocitrate lyase (3), and in vitro studies show that a persistent or dormant state can be generated by nutrient deprivation (4) and O 2 depletion (5).”
• Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling (2002, background): “, 1999), and a mutant strain lacking this gene is unable to mount a persistent infection in mice (McKinney et al., 2000).”
• Mycobacterium tuberculosis: Success through dormancy (2012, background): “Additionally, the pathogen upregulated genes involved in lipid metabolism confirming previous evidence that lipids are critical for virulence of Mtb (McKinney et al., 2000; Movahedzadeh et al., 2004; Brzostek et al., 2007; Chang et al., 2009; Nesbitt et al., 2010).”
• Transcriptional Response of Candida albicans upon Internalization by Macrophages (2004, background): “A role for the glyoxylate cycle in microbial virulence has now been reported in many organisms including Mycobacterium tuberculosis (25), and the plant pathogens Leptosphaera maculans (fungal [14]), Magnaporthe grisea (fungal [40]), and Rhodococcus fascians (bacterial [39]).”
• Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence (2005, background): “tuberculosis in mice and had little effect on replication during the acute phase of infectio”
• The glyoxylate cycle is required for fungal virulence (2001, background): “These findings in fungi, in conjunction with reports that isocitrate lyase is both upregulated and required for the virulence of Mycobacterium tuberculosis”
• Surviving the Acid Test: Responses of Gram-Positive Bacteria to Low pH (2003, background): “avium were previously shown to be induced in macrophages (102, 117), and recent evidence demonstrated the requirement of these genes for survival in macrophages and for persistence in mice (158).”