Evaluation of a nutrient starvation model of Mycobacterium tuberculosis persistence by gene and protein expression profiling

By J. Betts, P. Lukey, L. Robb, R. Mcadam, K. Duncan. Molecular Microbiology, 2002

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Genomic mapping of cAMP receptor protein (CRPMt) in Mycobacterium tuberculosis: relation to transcriptional start sites and the role of CRPMt as a transcription factor (2014, background): “To monitor the response to nutrient starvation (28), M.”
Inhibition of Respiration by Nitric Oxide Induces a Mycobacterium tuberculosis Dormancy Program (2003, background): “05–200 mM H 2 O 2 ), low iron (9), and nutrient deprivation (4) or exposure to the detergent sodium dodecyl sulfate (10).”
Mycobacterium tuberculosis: Success through dormancy (2012, background): “More recent work confirmed that nutrient-starved nonreplicating bacilli undergo a global downregulation of metabolic genes, including those involved in respiration (Betts et al., 2002).”
Cyclic AMP Signaling in Mycobacteria (2014, background): “%) genes comprise the two largest groups of genes in this predicted CRP Mt regulon, which is consistent with CRP Mt ’ s proposed role in M. tuberculosis persistence (46, 47, 53).”
Phosphorylation of InhA inhibits mycolic acid biosynthesis and growth of Mycobacterium tuberculosis (2010, methodology): “One hypothesis could be STPK-dependent phosphorylation of InhA is used by M. tuberculosis during the nonreplicating dormant state, known to correlate with a slowdown of cell division, energy metabolism and lipid biosynthesis (Betts et al., 2002).”