Mycobacterium tuberculosis isocitrate lyases 1 and 2 are jointly required for in vivo growth and virulence

By E. Muñoz-Elías, J. Mckinney. Nature Medicine, 2005

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Mycobacterial persistence requires the utilization of host cholesterol (2008, background): “Although the two Icl isozymes appear to serve redundant roles under most circumstances, icl1 mutants have a specific growth defect when propionate is the primary carbon source (28).”
Immune-responsive gene 1 protein links metabolism to immunity by catalyzing itaconic acid production (2013, background): “tuberculosis cannot persist in macrophages when both isoforms of icl are genetically knocked out (36).”
High-Resolution Phenotypic Profiling Defines Genes Essential for Mycobacterial Growth and Cholesterol Catabolism (2011, background): “tuberculosis H37Rv encodes a multifunctional protein with both isocitrate lyase and methylisocitrate lyase activity, which is required for both pathways [25,26].”
Interpreting Expression Data with Metabolic Flux Models: Predicting Mycobacterium tuberculosis Mycolic Acid Production (2009, background): “Bacterial metabolism plays an important role in TB pathology, both in terms of metabolic alterations associated with intracellular growth [9–12] as well as through the production of metabolic products associated with virulence – including mycolic acids [13–15].”