Germinal center dark and light zone organization is mediated by CXCR4 and CXCR5
By C. D. Allen, K. Ansel, C. Low, R. Lesley, H. Tamamura, N. Fujii, J. Cyster. Nature Immunology, 2004
824 citations recorded by the source corpus.
Subfields: Endocrine and Autonomic Systems, Immunology, Oncology
View Paper: https://www.semanticscholar.org/paper/8ef58c4ff70412cde385e1aa81bc8b77fa256cd3
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In Endocrine and Autonomic Systems
In Immunology
- J. Cyster
- A. Luster
- Christopher D. C. Allen
- Caroline L. Sokol
- T. Okada
- J. Griffith
- R. Lesley
- K. Ansel
In Oncology
Citations in the corpus
- Chemokines and chemokine receptors: positioning cells for host defense and immunity. (2014, background): “This process results in a bidirectional B cell migration between the two zones that allows for multiple cycles of proliferation and selection (169, 170).”
- Role of CXCR5 and CCR7 in Follicular Th Cell Positioning and Appearance of a Programmed Cell Death Gene-1High Germinal Center-Associated Subpopulation1 (2007, methodology): “5C) and FDC-M2 (25) (data not shown), and for the dark zone with an anti-CXCR4 Ab (Fig.”
- Germinal Center Dynamics Revealed by Multiphoton Microscopy Using a Photoactivatable Fluorescent Reporter (2010, neutral): “Finally, studies in which zonal migration was disrupted failed to show alterations in cell division, GC size, or development of high-affinity anti-NP antibodies (Allen et al., 2004; Nie et al., 2004).”
- A transcriptionally and functionally distinct PD-1+ CD8+ T cell pool with predictive potential in non-small cell lung cancer treated with PD-1 blockade (2018, neutral): “5 (2D1), -CD56 PE (CMSSB), - CD3 APC-eFluor780 (SK7), -Lag-3 FITC (3DS223H), -TIGIT PE (MBSA43), -2B4 FITC (eBioDM244), -CD137 FITC (4B4), -IL-2 PE (MQ1-17H12), -TNF-α APC (MAb11), - CD26 FITC (2A6), -CXCR5 Biotin (MU5UBEE), -ICOS FITC (ISA-3), -CD38 APC (HIT2), -Eomes eFluor660 (WD1928), -T-bet PE ”
- Germinal centres: role in B-cell physiology and malignancy (2008, background): “Some progress has also been made in the identification of the mechanisms that guide the trafficking of B cells between the dark and light zones, which appears to be mediated by chemokines that are possibly produced by stromal cell”
- Germinal-center organization and cellular dynamics. (2007, background): “In this regard is it notable that although CXCR4 protein was more abundant in dark-zone cells compared with light-zone cells, similar amounts of CXCR4 mRNA were detected in these cells (Allen et al., 2004).”
- Molecular mechanism and function of CD40/CD40L engagement in the immune system (2009, background): “GC B cells residing in the light zone are called centrocytes and are characterized by the expression of CXCR5 (102).”