Human Intestinal Barrier Function in Health and Disease

By J. König, J. Wells, Patrice D Cani, C. Garcia-Rodenas, T. MacDonald, A. Mercenier, Jacqueline Whyte, F. Troost, R. Brummer. Clinical and Translational Gastroenterology, 2016

719 citations recorded by the source corpus.

The gastrointestinal tract consists of an enormous surface area that is optimized to efficiently absorb nutrients, water, and electrolytes from food. At the same time, it needs to provide a tight barrier against the ingress of harmful substances, and protect against a reaction to omnipresent harmless compounds. A dysfunctional intestinal barrier is associated with various diseases and disorders. In this review, the role of intestinal permeability in common disorders such as infections with intestinal pathogens, inflammatory bowel disease, irritable bowel syndrome, obesity, celiac disease, non-celiac gluten sensitivity, and food allergies will be discussed. In addition, the effect of the frequently prescribed drugs proton pump inhibitors and non-steroidal anti-inflammatory drugs on intestinal permeability, as well as commonly used methods to assess barrier function will be reviewed.

Subfields: Gastroenterology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/62bb061a353a3ba9c89d3264f491b8ec0863f2c8

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Gastroenterology

1. Severine Vermeire
2. M. Vancamelbeke

In Molecular Biology

1. K. Kowalski
2. Severine Vermeire
3. A. Mulak
4. Patrice D Cani
5. M. Vancamelbeke

In Surgery

1. Severine Vermeire
2. Patrice D Cani
3. M. Vancamelbeke

Citations in the corpus

• The intestinal barrier: a fundamental role in health and disease (2017, background): “Studies on the ability of PPIs to cause barrier defects have mainly focused on gastric permeability [72].”
• Human gut microbiome: hopes, threats and promises (2018, background): “As previously indicated, gut microbes are constantly interacting with intestinal epithelial cells; however, in normal conditions, the gut barrier function is highly efficient due to complex multifaceted mechanisms (ie, tight-junction proteins, thickness and composition of the mucus layer, presence o”
• Brain-Gut-Microbiota Axis in Alzheimer’s Disease (2019, background): “coli strains, Salmonella, Shigella, Helicobacter pylori, Vibrio, or Clostridium mediate changes in tight junctions.(51) The exotoxin of Bacteroides fragilis disrupts adherence junctions by cleavage of cell adhesion molecule––E-cadherin.”
• The Role of Zinc in Antiviral Immunity (2019, background): “Alcohol also stimulates microbial dysbiosis and gastrointestinal permeability (173), a phenotype that can increase the likelihood of viral infection in the gut (174).”
• Negative Effects of a High-Fat Diet on Intestinal Permeability: A Review. (2019, background): “Interestingly, because FAS is an insulin-sensitive enzyme, FAS downregulation in the setting of HFD-induced insulin resistance (diabetes or metabolic syndrome) may provide additional insight into the pathophysiology of enhanced intestinal permeability and associated endotoxemia seen in these patient”