Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons.

By Gabriela G. Loots, R. Locksley, Catherine M. Blankespoor, Zhi-En Wang, Webb Miller, Edward M. Rubin, Kelly A. Frazer. Science, 2000

864 citations recorded by the source corpus.

Subfields: Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8ec3f279fec2f99ce5ced955dd630c865440bdec

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Citations in the corpus

High-resolution profiling of histone methylations in the human genome. (2007, methodology): “Comparative genomics has been used to predict a set of highly conserved noncoding sequences as enhancers (Loots et al., 2000; Miller et al., 2004; Pennacchio and Rubin, 2001).”
PEDLA: predicting enhancers with a deep learning-based algorithmic framework (2016, background): “The first genome-scale efforts to identify enhancers were based on evolutionary sequence conservation (19-22) because regulatory sequences are likely to evolve under negative evolutionary selection (23-25).”
Comparative genome analysis delimits a chromosomal domain and identifies key regulatory elements in the α globin cluster (2001, methodology): “Most recently it has been suggested that regulatory elements should be found in non-coding regions with >70% identity over at least 100 bp (10).”
Genetics of global gene expression (2006, background): “Moreover, the existence of regulatory elements that are located far from the genes they regulat”
Sequencing and comparison of yeast species to identify genes and regulatory elements (2003, background): “Cross-species conservation has previously been used to identify putative genes or regulatory elements in small genomic region”
Long-range control of gene expression: emerging mechanisms and disruption in disease. (2005, background): “A conserved element was identified by cross-species sequence comparison in the intergenic space between the Il4 and Il13 cytokine genes (Loots et al. 2000).”
Initial sequencing and comparative analysis of the mouse genome (2002, methodology): “Mouse proteins predicted to be homologues (E , 10(24)) of other proteins were classified into one of six taxonomic groupings: (1) rodent-specific; (2) mammalian-specific; (3) chordate-specific; (4) metazoan-specific; (5) eukaryote-specific; and (6) other (Fig.”
The evolution of transcriptional regulation in eukaryotes. (2003, methodology): “Exceptions might include the promoters of genes encoding proteins that tolerate many amino acid substitutions, are under balancing selection, or whose introns contain regulatory sequences (e.g., IL-4 and IL-13 in mammals: Loots et al. 2000).”
VISTA : visualizing global DNA sequence alignments of arbitrary length (2000, background): “Comparative sequence analysis has enabled identification of regulatory non-coding regions (Loots et al., 2000; Dubchak et al., 2000), and location of coding exons (Batzoglou et al., 2000) using purely computational means.”
Massively parallel functional dissection of mammalian enhancers in vivo (2012, background): “Relationship between evolutionary and functional constraint Evolutionary constraint in noncoding, regulatory DNA has frequently served as a proxy for functional constrain”