Optical Deconstruction of Parkinsonian Neural Circuitry

By Viviana Gradinaru, Murtaza Z Mogri, K. Thompson, Jaimie M. Henderson, Karl Deisseroth. Science, 2009

1,542 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/8e2009732a1db192b2a54f187c08cedb80e0ad37

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In Cellular and Molecular Neuroscience

In Neurology

Citations in the corpus

Molecular and cellular approaches for diversifying and extending optogenetics. (2010, methodology): “…reward, as well as to probe the operation of neural circuits important in a number of brain diseases including Parkinson’s disease and epilepsy (Adamantidis et al., 2007; Airan et al., 2009; Cardin et al., 2009; Gradinaru et al., 2009; Sohal et al., 2009; Tønnesen et al., 2009; Tsai et al., 2009).”
Noninvasive deep brain stimulation via temporally interfering electric fields (2017, positive): “, 2009), in a fashion different from direct optogenetic control of local cells (Gradinaru et al., 2009).”
Computational models of basal-ganglia pathway functions: focus on functional neuroanatomy (2013, background): “…hypothesis is yet rather unspeciﬁc: DBS of the STN in Parkinson’s disease patients (which is assumed to inhibit spiking activity in this nucleus; Gradinaru et al., 2009) impaired working-memory performance in a spatial delayed response task (Hershey et al., 2008) and in an n-back task (Alberts…”
The effects of electrical microstimulation on cortical signal propagation (2010, background): “It should be noted that high-frequency, neuronal element–specific, optical-stimulation (90–130 Hz) experiments found that the antidromic stimulation of the afferents of the subthalamic nucleus, the main target of deep brain stimulation, was the only optogenetic intervention that robustly ameliorated”
Recombinase-driver rat lines: tools, techniques, and optogenetic application to dopamine-mediated reinforcement (2011, positive): “…have enabled substantial advances in neuroscience and have made possible new approaches for circuit analysis with optogenetics (Tsai et al., 2009; Gradinaru et al., 2009; Lobo et al., 2010; Kravitz et al., 2010; Witten et al., 2010; Tye et al., 2011), a generalizable approach for optogenetic…”
Closed-loop and activity-guided optogenetic control. (2015, positive): “For in vivo experiments, the fact that during behavior microbial opsin-expressing projections can be either excited (Gradinaru et al., 2009; Tye et al., 2011; Stuber et al., 2011) or inhibited (Tye et al., 2011; Stuber et al., 2011) is useful for establishing necessity and sufficiency of…”
The Development and Application of Optogenetics (2011, methodology): “Light can be delivered not to somata but to axons, thereby recruiting cells defined by virtue of their wiring without any genetic information about the downstream target required (Gradinaru et al. 2007, 2009; Lee et al. 2010; Petreanu et al. 2007).”