Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter.

By Y. Wan, R. Flavell. Proceedings of the National Academy of Sciences of the United States of America, 2005

652 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8e1f85e3833741988ed1c7c5af9417dfaafb79b7

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In Immunology

Citations in the corpus

IL-2 Receptor β-Dependent STAT5 Activation Is Required for the Development of Foxp3+ Regulatory T Cells1 (2007, background): “For example, CD25 is also expressed on activated effector T cells; furthermore, CD25 is not expressed on all Tregs as was recently demonstrated using foxp3 or foxp3 knock-in mice (33, 34).”
Selective depletion of Foxp3+ regulatory T cells induces a scurfy-like disease (2007, result): “Phenotypic characterization of DEREG mice not only revealed an eGFP expression pattern similar to that of previously published Foxp3 reporter mice (20, 21) but also showed that DT treatment, in contrast to conventional T reg cell depletion strategies, allows for effi cient and selective depletion of”
Regulatory T Cells and Foxp3 (2011, background): “sion is largely restricted to a subset of T cells with suppressor function (17, 18).”
Th17 cells express interleukin-10 receptor and are controlled by Foxp3− and Foxp3+ regulatory CD4+ T cells in an interleukin-10 dependent manner (2011, background): “Foxp3 reporter mice (Wan and Flavell, 2005), IL-17A eGFP reporter mice (unpublished data), and IL-10 eGFP mice (Kamanaka et al.”
TGF-beta: a master of all T cell trades. (2008, neutral): “In vitro activation of CD4+CD25− or CD4+Foxp3− T cells in the presence of TGF-β leads to their acquisition of T cell suppressive activity, which is associated with the induction of Foxp3 expression (Chen et al., 2003b; Fantini et al., 2004; Wan and Flavell, 2005; Zheng et al., 2002).”
Foxp3 in control of the regulatory T cell lineage (2007, background): “More recently, genetic marking of Foxp3-expressing cells by insertion of a sequence encoding a fluorescent reporter protein into the Foxp3 locus ( Foxp3 gfp ) showed that, in mice, within the lymphoid compartment, Foxp3 protein expression is limited to αβ T cell”