Forging a signature of in vivo senescence

By N. Sharpless, C. Sherr. Nature Reviews. Cancer, 2015

1,029 citations recorded by the source corpus.

Subfields: Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/8ddad73b585e5f5b4d28c95cc2dcbe84489621d1

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Citations in the corpus

Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018 (2018, background): “and (5) presence of so-called “senescence-associated heterochromatic foci” (SAHF) [934, 941].”
Mechanisms and functions of cellular senescence. (2018, neutral): “In addition to their potential side effects, the evaluation of senolytic compounds is compromised by limitations such as the lack of universal senescence biomarkers and the heterogeneity of senescent phenotypes in vivo (20).”
Unmasking Transcriptional Heterogeneity in Senescent Cells (2017, methodology): “Many senescence-associated markers result from altered transcription, but the senescent phenotype is variable, and methods for clearly identifying senescent cells are lacking [10].”
Hallmarks of Cellular Senescence. (2018, neutral): “However, SAHFs are not universal markers and are mainly observed in OIS [3].”
Naturally occurring p16Ink4a-positive cells shorten healthy lifespan (2016, neutral): “ATTAC was also not induced in peripheral blood T lymphocytes that robustly engage endogenous p16 Ink4a with aging without concomitant expression of multiple senescence markers 2, 13 (Extended Data Fig.”
Senescence and aging: Causes, consequences, and therapeutic avenues (2018, background): “If senescent cells are eliminated and account for ∼1–5% of cells in aged tissues (Sharpless and Sherr, 2015), where do they go? Apoptotic cells mark themselves for phagocytosis by the immune system with special “find me” and “eat me” signals.”
Mechanisms of Cellular Senescence: Cell Cycle Arrest and Senescence Associated Secretory Phenotype (2021, background): “However, expression of p21WAF1/CIP1 does not persist in senescent cells as it is mainly required for induction of senescence (Stein et al., 1999; Sharpless and Sherr, 2015; He and Sharpless, 2017; Song et al., 2020).”