Photodegradable hydrogels for dynamic tuning of physical and chemical properties

By April M. Kloxin, A. Kasko, Chelsea N. Salinas, K. Anseth. Science, 2009

1,598 citations recorded by the source corpus.

We report a strategy to create photodegradable poly(ethylene glycol)–based hydrogels through rapid polymerization of cytocompatible macromers for remote manipulation of gel properties in situ. Postgelation control of the gel properties was demonstrated to introduce temporal changes, creation of arbitrarily shaped features, and on-demand pendant functionality release. Channels photodegraded within a hydrogel containing encapsulated cells allow cell migration. Temporal variation of the biochemical gel composition was used to influence chondrogenic differentiation of encapsulated stem cells. Photodegradable gels that allow real-time manipulation of material properties or chemistry provide dynamic environments with the scope to answer fundamental questions about material regulation of live cell function and may affect an array of applications from design of drug delivery vehicles to tissue engineering systems.

Subfields: Biomaterials, Biomedical Engineering, Molecular Medicine

View Paper: https://www.semanticscholar.org/paper/8dd42684c931290179ade7b71b511a5b276775c0

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Citations in the corpus

Macroporous nanowire nanoelectronic scaffolds for synthetic tissues (2012, neutral): “(5) The silicon substrate was then coated with MMA and PMMA double layer resist, the resist was patterned over the chosen SU-8 ribbons, and then nonsymmetrical Cr/ Pd/Cr (1.”
In situ Forming Injectable Hydrogels for Drug Delivery and Wound Repair (2018, neutral): “For example, degradative approaches can be used for the on demand release of therapeutic molecules from localized depots or to locally rearrange hydrogel properties to direct cellular growth and migration [105].”
Some hydrogels having novel molecular structures (2010, methodology): “The Anseth group [106,107] recently built on upon the work of Shoichet and Johnson to generate hydrogel materials which possessed both chemical and mechanical patterns through degradation.”
Control of stem cell fate by physical interactions with the extracellular matrix (2009, methodology): “Recent studies have also demonstrated a novel method by which the shape of human MSCs can be dynamically modified in such hydrogels by creating photodegradable poly(ethylene glycol)-based scaffolds (Kloxin et al., 2009).”
Stem Cell Organoid Engineering (2016, positive): “For example, by incorporating biomolecule-binding sites into a hydrogel and masking their active sites with a photo-degradable moiety, it was possible to control MSC migration within a PEG hydrogel (Gjorevski et al., 2014; Kloxin et al., 2009).”