Macroporous nanowire nanoelectronic scaffolds for synthetic tissues

By B. Tian, Jia Liu, Tal Dvir, Lihua Jin, Jonathan H. Tsui, Quan Qing, Zhigang Suo, Robert Langer, Daniel S. Kohane, Charles M. Lieber. Nature Materials, 2012

608 citations recorded by the source corpus.

The development of three-dimensional (3D) synthetic biomaterials as structural and bioactive scaffolds is central to fields ranging from cellular biophysics to regenerative medicine. As of yet, these scaffolds cannot electrically probe the physicochemical and biological micro-environments throughout their 3D and macroporous interior, although this capability could have a marked impact in both electronics and biomaterials. Here, we address this challenge using macroporous, flexible and free-standing nanowire nanoelectronic scaffolds (nanoES), and their hybrids with synthetic or natural biomaterials. 3D macroporous nanoES mimic the structure of natural tissue scaffolds, and they were formed by self-organization of coplanar reticular networks with built-in strain and by manipulation of 2D mesh matrices. NanoES exhibited robust electronic properties and have been used alone or combined with other biomaterials as biocompatible extracellular scaffolds for 3D culture of neurons, cardiomyocytes and smooth muscle cells. Additionally, we show the integrated sensory capability of the nanoES by real-time monitoring of (i) the local electrical activity within 3D nanoES/cardiomyocyte constructs, (ii) the response of 3D nanoES based neural and cardiac tissue models to drugs, and (iii) distinct pH changes inside and outside tubular vascular smooth muscle constructs.

Subfields: Biomedical Engineering, Cellular and Molecular Neuroscience, Polymers and Plastics

View Paper: https://www.semanticscholar.org/paper/a2e3dd875e3921aac870aa425019584caf823e20

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Citations in the corpus

Fractal design concepts for stretchable electronics (2014, background): “square, (2) thick mesh, (3) thin mesh, (4) horizontal and vertical stripes separated by a spacer, (5) Peano curve, (6) Hilbert curve, (7) Serpentine Greek”
Flexible electronics under strain: a review of mechanical characterization and durability enhancement strategies (2016, background): “nanowire sensors embedded in a tissue scaffold [442].”
Next-generation probes, particles, and proteins for neural interfacing (2017, background): “One approach is to embed interconnects and electronics in a mesh-like structure, around which cell and tissue can intercalate (73).”
Syringe injectable electronics (2015, methodology): “7 Brain tissue preparation for chronic immunostaining Key steps for brain tissue immunostaining are as follows: (1) 4-5 weeks after the surgery, mice underwent transcardial perfusion (40 mL 1x PBS) and were fixed with 4% formaldehyde (Sigma-Aldrich Corp.”