Microdomains of intracellular Ca2+: molecular determinants and functional consequences.

By R. Rizzuto, T. Pozzan. Physiological Reviews, 2006

1,151 citations recorded by the source corpus.

Subfields: Molecular Biology, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/8d3844c9a415d396d28ef8b7068954fb60ccae40

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Citations in the corpus

Role of Mitochondrial Ca2+ in the Regulation of Cellular Energetics (2012, background): “While very controversial for many years, numerous genetically generated optical probes, as well as exogenous probes, have demonstrated that the mitochondrial Ca2+ concentration (Cam) responds to rapid changes in gross or regional changes in cytosolic Ca2+ (Cac), implying a dynamic import and export ”
Mitochondria and neuronal activity. (2007, background): “However, high local Ca(2) domains of tens of micromolar in the vicinity of voltage-operated Ca(2) channels or Ca(2) release sites of the endoplasmic reticulum (183) might be necessary for fast [Ca(2) ]m transients (71, 164).”
Calcium and apoptosis: ER-mitochondria Ca2+ transfer in the control of apoptosis (2008, background): “The existence of subcellular domains in which [Ca2þ ] largely exceeds the bulk cytosolic values have been postulated for a long time, but only in the last decade, these values have been directly measured and their primary function in controlling some cell functions, beyond the classical function in ”
Ca2+ signalling checkpoints in cancer: remodelling Ca2+ for cancer cell proliferation and survival (2008, background): “The Ca 2+ toolkit Every cell expresses a unique complement of components from a Ca 2+ signalling toolkit that enables it to generate intracellular Ca 2+ signals of a particular amplitude, time course and intracellular locatio”
Fiber types in mammalian skeletal muscles. (2011, background): “In spite of the low affinity of the uniporter (1–10 M), due to specific localization of mitochondria close to the SR calcium release channels and the formation of microdomains with high calcium concentration (654), mitochondria can take up calcium once released from RyR (226, 662).”
Mitochondria: In Sickness and in Health (2012, background): “MAMs create unique environments or platforms for the localization and activity of components that function in shared interorganellar functions, such as Ca2+ homeostasis and lipid biosynthesis (Hayashi et al., 2009; Rizzuto and Pozzan, 2006; Voelker, 2009).”
The Convallis Rule for Unsupervised Learning in Cortical Networks (2013, background): “Linear addition of P(V ) and D(V ) would be expected due to their implementation by separate coincidence detectors, triggered by spatially separated calcium sources [64].”
Imaging interorganelle contacts and local calcium dynamics at the ER-mitochondrial interface (2010, neutral): “This microdomain would attain activation of the low-affinity mitochondrial Ca uniporter (Csordás et al., 1999; Rizzuto et al., 1993, 1998; Rizzuto and Pozzan, 2006; Szalai et al., 2000).”
Calcium and cancer: targeting Ca2+ transport (2007, background): “Unlike the SR/ER, the mitochondria is not a large store for Ca 2+ ; however, it may fine tune the Ca 2+ signa”
Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways. (2008, background): “Moreover, mitochondria associate directly and are in close communication with the ER.(30) It is noteworthy that we did not observe evidence of caspase activation in BEAS-2B cells, in spite of the fact that that NH2-PS leads to increased [Ca(2) ]i, mitochondrial damage, ATP depletion, and cytotoxicit”
Self-eating and self-killing: crosstalk between autophagy and apoptosis (2007, background): “Increases in free Ca 2+ ion concentrations in the cytosol ([Ca 2+ ] c ), Ca 2+ efflux from the ER and Ca 2+ overload of mitochondria all constitute prominent pro-apoptotic signal”