Cationic polystyrene nanosphere toxicity depends on cell-specific endocytic and mitochondrial injury pathways.

By Tian Xia, M. Kovochich, M. Liong, J. Zink, A. Nel. ACS Nano, 2008

654 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/3b9a2380a9d8f371c977ae6dc812239556e56592

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In Biomaterials

1. N. Bertrand
2. A. Nel
3. Tian Xia
4. Xiaoyang Xu
5. J. Zink
6. M. Liong
7. O. Farokhzad
8. A. Garcia‐Bennett

In Molecular Biology

1. N. Bertrand
2. Xiaoyang Xu
3. O. Farokhzad
4. Huan Meng
5. Tian Xia
6. Liying Wang
7. A. Nel
8. M. Liong

Citations in the corpus

• Polyethyleneimine coating enhances the cellular uptake of mesoporous silica nanoparticles and allows safe delivery of siRNA and DNA constructs. (2009, methodology): “While PEI is quite effective for complexing and delivering nucleic acids, polymer-based delivery of DNA and siRNA often leads to cytotoxicity due to damage to the surface membrane, lysosomes, and mitochondria.(21,26,29) However, on the basis of the observation that decoration of MSNP with a 1.”
• Better safe than sorry: Understanding the toxicological properties of inorganic nanoparticles manufactured for biomedical applications. (2010, background): “[127] have shown, in a comprehensive in vitro study using five different cell lines that the”
• Interactions of nanomaterials and biological systems: implications to personalized nanomedicine (2012, background): “Interestingly, the mechanism of toxicity for cationic nanospheres was dependent on the cell type and uptake mechanism [219].”
• Comparison of the Mechanism of Toxicity of Zinc Oxide and Cerium Oxide Nanoparticles Based on Dissolution and Oxidative Stress Properties (2008, neutral): “Cellular viability was determined by the MTS assay, which looks at the reduction of 3-(4,5dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4sulfophenyl)-2H-tetrazolium (MTS) to formazan in viable cells.(40) Briefly, 25 10(3) cells were plated onto 96 multiwell plates (Costar; Corning, NY).”
• (Nano)plastics in the environment - Sources, fates and effects. (2016, background): “Earlier, Xia et al. showed that 60 nm PS nanospheres were highly toxic towards macrophage (RAW 264.7) and epithelial (BEAS2B) cells (Xia et al., 2008).”
• Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity (2013, background): “Oxidative stress may be caused directly by CNT-induced ROS in the vicinity or inside the cell or could arise more indirectly due to the effects of internalized CNT on mitochondrial respiration [114] or in depletion of antioxidant species within the cell [64].”
• Understanding biophysicochemical interactions at the nano-bio interface. (2009, background): “In addition to entry into endosomal compartments, engineered nanoparticles exert important effects on other organelle”
• Autophagy and lysosomal dysfunction as emerging mechanisms of nanomaterial toxicity (2012, background): “In the case of the cationic polystyrene nanosphere, a “proton sponge” theory has been proposed to explain lysosomal rupture, in which the high proton buffering capacity of the particle surface amines results in excessive proton pump activity and osmotic swelling [58].”
• Nanomaterial cytotoxicity is composition, size, and cell type dependent (2010, background): “Since these characteristics contribute to particle uptake and variable intracellular responses [59], we included these occasionally overlooked factors into our design, in accordance with recent trends in nanotoxicology publications [41,42,61].”