Peroxynitrite reductase activity of bacterial peroxiredoxins

By R. Bryk, P. Griffin, C. Nathan. Nature, 2000

684 citations recorded by the source corpus.

Subfields: Biochemistry, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/8d20b63130f09cfdf7c2c317c24739c3c882845b

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Citations in the corpus

Peroxynitrite: biochemistry, pathophysiology and development of therapeutics (2007, background): “Bacterial and parasitic peroxiredoxins have been shown to readily and catalytically reduce peroxynitrite to nitrite through the reaction of the peroxidatic cysteine ( k ∼1 × 10 6 M −1 s −1 ), which in turn is reduced back to the resting state via thiol-containing reducing substrates such as thiore”
Peroxynitrite, a Stealthy Biological Oxidant* (2013, background): “The endogenous systems that cope with the toxic effects of peroxynitrite were established in initial work on microbial systems (80, 81).”
Nitrate, bacteria and human health (2004, background): “There are a few reports of the identification of bacterial peroxynitrite and hydroxylamine reductase”
Nitric oxide and the immune response (2001, background): “typhimurium are equipped with peroxiredoxins that detoxify ONOO − to nitrit”
Redox chemistry of biological thiols (2010, background): “Prxs exhibit high reactivity with ONOOH (keff= ~10 –10M 1 s 1 at pH 7) compared to typical rate constants with other thiols, and are proposed to be specific ONOOH scavengers in vivo [56–59].”
Nitric oxide and peroxynitrite in health and disease. (2007, background): “Potent enzymatic scavenging systems to detoxify peroxynitrite are found in pathogenic microorganisms (155, 156).”
Nitric oxide and redox mechanisms in the immune response (2011, background): “Bacteria also evade macrophage killing by neutralizing reactive nitrogen intermediates [74].”
Oxygen radicals, nitric oxide, and peroxynitrite: Redox pathways in molecular medicine (2018, background): “In this context, a notable observation was made in the early 2000s by Nathan and coworkers (103) indicating that a class of thiol-containing antioxidant enzymes in bacteria, the peroxiredoxins, react at large rates with peroxynitrite and reduce it to NO2 due to the occurrence of “fast reacting thiol”
Chemical biology of peroxynitrite: kinetics, diffusion, and radicals. (2009, background): “The bactericidal and parasiticidal potency of peroxynitrite can be partially or totally neutralized by effective antioxidant mechanisms in the pathogens, such as bacterial and parasitic peroxiredoxins (31, 104).”