Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?

By H. Peinado, D. Olmeda, A. Cano. Nature Reviews. Cancer, 2007

3,237 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/7df3d7e30c8b32180600ded98ce9eab5a87a6dfd

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Citations in the corpus

The epithelial-mesenchymal transition generates cells with properties of stem cells. (2008, neutral): “…confer malignant traits, such as motility, invasiveness, and resistance to apoptosis, on neoplastic cells (Cheng et al., 2007; Comijn et al., 2001; Hartwell et al., 2006; Huber et al., 2005; Mani et al., 2007; Oft et al., 2002; Peinado et al., 2007; Savagner et al., 2005; Yang et al., 2004, 2006).”
Cadherin switching (2008, background): “Disrupting N-cadherin function in granulosa cells using inhibitory antibodies or an inhibitory peptide induces apoptosis (Makrigiannakis et al., 1999; Peluso et al., 1996).”
EMT, the cytoskeleton, and cancer cell invasion (2009, background): “Transcriptional repression of E-cadherin is mediated by a list of transcription factors, among them intensely studied factors like Snail1 (Snail), Snail2 (Slug), ZEB1 (δEF1), ZEB2 (Sip1), E47, and Twist [44] (Fig.”
Direct regulation of TWIST by HIF-1α promotes metastasis (2008, background): “Snail is a zinc-finger transcriptional repressor shown to induce EMT through the repression of E-cadherin expression, one of the hallmarks of EM”
Epithelial-mesenchymal transitions in development and disease. (2009, background): “Snail, Zeb, E47, and KLF8 factors bind to and repress the activity of the E-cadherin promoter (Peinado et al., 2007; Wang et al., 2007b) (see Table S1 for references), whereas factors such as Twist, Goosecoid, E2.”
Experimental adaptation of an influenza H5 haemagglutinin (HA) confers respiratory droplet transmission to a reassortant H5 HA/H1N1 virus in ferrets (2012, background): “Several transcriptional repressors were identified as inducers of EMT, including SNAI, Slug (Snail-2), E47, Twist, and the Zeb factors (8).”
Epithelial-mesenchymal transition: at the crossroads of development and tumor metastasis. (2008, background): “A recent review has presented an excellent survey on the published reports of their expression in human cancers (Peinado et al., 2007).”
Acquisition of Epithelial-Mesenchymal Transition phenotype of gemcitabine-resistant pancreatic cancer cells is linked with activation of Notch signaling pathway (2009, neutral): “helix-loop-helix factors such as Twist, ZEB1, ZEB2/SIP1, and TCF3/ E47/E12 (15).”
The ZEB/miR‐200 feedback loop—a motor of cellular plasticity in development and cancer? (2010, background): “©2010 EuropEan MolEcular Biology organization EMBo reports 3 in controlling typical EMt-associated properties, such as loss of cell– cell adhesion and gain of cellular motility, are already extensively described (gregory et al, 2008b; peinado et al, 2007; Vandewalle et al, 2009).”
Involvement of members of the cadherin superfamily in cancer. (2009, background): “Further, transcriptional deregulation of epithelial differentiation has been much explored lately (Peinado et al. 2007).”
The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs (2009, background): “Increasing evidence indicates that aberrant activation of EMT triggers malignant tumour progressio”
Vimentin regulates EMT induction by Slug and oncogenic H-Ras and migration by governing Axl expression in breast cancer (2011, background): “Expression of some of these transcription factors, such as Slug and Snail, has also been associated with a poor prognosis in a variety of human cancers (reviewed in Peinado et al., 2007).”