The Mitochondrial Production of Reactive Oxygen Species: Mechanisms and Implications in Human Pathology

By G. Lenaz. IUBMB Life - A Journal of the International Union of Biochemistry and Molecular Biology, 2001

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Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus (2020, background): “Superoxide anion (O2 ) is the main form of free radical species produced by MRC and NOX enzymes in the beta cells [52].”
Mitochondrial α-Ketoglutarate Dehydrogenase Complex Generates Reactive Oxygen Species (2004, background): “These studies revealed that inhibiting complexes I and III of the mitochondrial respiratory chain with specific mitochondrial toxins, such as rotenone and antimycin A, resulted in high rates of ROS production (Turrens, 1997; Murphy et al., 1999; Lenaz, 2001).”
Consensus Paper: Pathological Role of the Cerebellum in Autism (2012, background): “The free radicals are generated endogenously during oxidative metabolism and energy production by mitochondria, and the electron transport chain (ETC) in mitochondria is a prime source for ROS generation [113].”
Mitochondria-Ros Crosstalk in the Control of Cell Death and Aging (2011, background): “At least, ten mammalian mitochondrial enzymes contribute to ROS production [17, 19] even if their capacity of ROS producing greatly differ in a tissues-specific manner [20].”
Mechanisms of Nanoparticle-Induced Oxidative Stress and Toxicity (2013, background): “result in damage to membrane phospholipids inducing mitochondrial membrane depolarization [53].”