Molecular Mechanisms Linking Oxidative Stress and Diabetes Mellitus

By Habib Yaribeygi, T. Sathyapalan, S. Atkin, Amirhossein Sahebkar. Oxidative Medicine and Cellular Longevity, 2020

604 citations recorded by the source corpus.

Type 2 diabetes mellitus (T2DM) is the most prevalent metabolic disorder characterized by chronic hyperglycemia and an inadequate response to circulatory insulin by peripheral tissues resulting in insulin resistance. Insulin resistance has a complex pathophysiology, and it is contributed to by multiple factors including oxidative stress. Oxidative stress refers to an imbalance between free radical production and the antioxidant system leading to a reduction of peripheral insulin sensitivity and contributing to the development of T2DM via several molecular mechanisms. In this review, we present the molecular mechanisms by which the oxidative milieu contributes to the pathophysiology of insulin resistance and diabetes mellitus.

Subfields: Clinical Biochemistry, Endocrinology, Diabetes and Metabolism, Physiology

View Paper: https://www.semanticscholar.org/paper/454b6df71061c9fbcd7ad608bc898e381c269ec1

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Citations in the corpus

• Advanced Glycation End-Products (AGEs): Formation, Chemistry, Classification, Receptors, and Diseases Related to AGEs (2022, background): “Chronic oxidative stress and an overload of AGEs in serum, despite acting on many molecular pathways [178], can inhibit two receptors, AGE-R1 and SIRT-1, which are responsible for recognizing and repressing AGEs [179].”