Vascularization in tissue engineering.

By J. Rouwkema, Nicolas Rivron, C. V. van Blitterswijk. Trends in Biotechnology, 2008

1,164 citations recorded by the source corpus.

Subfields: Biomaterials, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/8b7fb2078dd153d73226d01a2107d580d1033bba

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Citations in the corpus

Additive manufacturing of tissues and organs (2012, background): “tation, due to an inflammatory wound-healing response and the hypoxia-induced endogenous release of angiogenic growth factors [152].”
Development of a magnetic microrobot for carrying and delivering targeted cells (2018, background): “The porous scaffold structure mimics the extracellular matrix, allowing the easy supply of nutrients for tissue vascularization to yield functional tissues and organs (43, 44) and cell growth (45).”
Bioprinting 3D microfibrous scaffolds for engineering endothelialized myocardium and heart-on-a-chip (2016, positive): “Vascularization presents one of the most critical steps during the development of many functional tissue and organ systems since mature networks of blood vessels enable the transport of nutrient, oxygen, and wastes to/from the tissues [19,20,50,51].”
Recent advances in bone tissue engineering scaffolds (2012, background): “The key factors for an ideal scaffold for bone tissue engineering are - i) macro- (pore size >100 μm) and micro-porosity (pore size < 20 μm); ii) interconnected open porosity for in vivo tissue in-growth; iii) sufficient mechanical strength and controlled degradation kinetics for proper load transfe”
Current trends in the design of scaffolds for computer-aided tissue engineering. (2014, background): “In this scenario, the incorporation of a functional vasculature able to meet mass transport requirements represents a major concern [137,138].”
Tissue Engineering for Clean Meat Production (2019, background): “, 2009), such as co-culture with mural cells (Sims, 1986; Allt and Lawrenson, 2001; Bergers and Song, 2005; von Tell et al., 2006; Rouwkema et al., 2008), fibroblasts (Levenberg et al.”
Vascularization and Angiogenesis in Tissue Engineering: Beyond Creating Static Networks. (2016, background): “Tissues generated for this purpose will generally be of a size larger than the diffusional limit for nutrients and oxygen [2].”
Scaffold-Free Vascular Tissue Engineering Using Bioprinting (2009, background): “Despite these advances, viability upon implantation remains problematic as infiltration of surrounding vessels or connection of microvascularized constructs with the host vasculature takes days to weeks, predisposing the tissue to ischemia [45].”
Vascularization Strategies for Tissue Engineering (2009, positive): “Likewise, when tissues grown in the laboratory are implanted into the body, this diffusion limitation allows only cells within 100–200 mm from the nearest capillary to survive.(2) Thus, it is critical that a tissue be prevascularized before implantation with proper consideration given to the cell an”
Organ printing: Tissue spheroids as building blocks (2009, background): “Recent reviews on the problem of vascularization in tissue engineered constructs based on using biodegradable solid scaffolds also state that after two decades of intensive efforts the effective solution of this problem has not yet been found [19–21].”