Recent advances in bone tissue engineering scaffolds
By S. Bose, M. Roy, A. Bandyopadhyay. Trends in Biotechnology, 2012
2,081 citations recorded by the source corpus.
Bone disorders are of significant concern due to increase in the median age of our population. Traditionally, bone grafts have been used to restore damaged bone. Synthetic biomaterials are now being used as bone graft substitutes. These biomaterials were initially selected for structural restoration based on their biomechanical properties. Later scaffolds were engineered to be bioactive or bioresorbable to enhance tissue growth. Now scaffolds are designed to induce bone formation and vascularization. These scaffolds are often porous, biodegradable materials that harbor different growth factors, drugs, genes or stem cells. In this review, we highlight recent advances in bone scaffolds and discuss aspects that still need to be improved.
Subfields: Biomedical Engineering, Rheumatology
View Paper: https://www.semanticscholar.org/paper/49f9f9c1847e7d3abe54bb7f3da449560a146734
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- Nureddin Ashammakhi
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Citations in the corpus
- Review of Multifarious Applications of Poly (Lactic Acid) (2016, background): “to suit various applications, and the ability to fabricate into various shapes with desired pore morphologic features([108,122]).”
- Bone grafts: which is the ideal biomaterial? (2019, background): “For instance, Fielding, Bandyopadhyay, and Bose (2012) demonstrated that the addiction of silicon and zinc oxides to beta- tricalcium phosphate increased compressive strength to 2.5- fold and cell viability to 92%; however, clinical evidence is still lacking.”
- Bioinks and bioprinting technologies to make heterogeneous and biomimetic tissue constructs (2019, methodology): “Concurrent with the advance of additive manufacturing techniques, 3D printers were rapidly tailored for fabricating bone tissue [14], blood vessels [15], and simple organs such as skin [16,17].”
- Biodegradable magnesium alloys for orthopaedic applications: A review on corrosion, biocompatibility and surface modifications. (2016, background): “These polymers can also use for surface modifications, hydrogel scaffold synthesis and housing drugs for delivery [102].”
- Bone Regeneration Based on Tissue Engineering Conceptions — A 21st Century Perspective (2013, neutral): “However, it is beyond the scope of this review to present all of them in detail and a number of comprehensive reviews have been published recently on this topic (2, 5, 79, 97, 101, 160-161).”