Pathoanatomy of Parkinson’s disease

By H. Braak, E. Braak. Journal of Neurology, 2000

689 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Neurology

View Paper: https://www.semanticscholar.org/paper/8b5f7fd5327c5c216fc2c47744ecc64b9613b751

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In Cellular and Molecular Neuroscience

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Citations in the corpus

Parkinson-Like Neurodegeneration Induced by Targeted Overexpression of α-Synuclein in the Nigrostriatal System (2002, background): “, the pathological hall marks of PD (Spillantini et al., 1997, 1998; Baba et al., 1998; Irizarry et al., 1998; Takeda et al., 1998; Braak and Braak, 2000).”
Where Does Parkinson Disease Pathology Begin in the Brain? (2002, background): “Although it is probable that the deterioration of the somatomotor system is attributable not only to nigrostriatal damage but also to detrimental events within other nerve cell populations and systems of the brain (19, 20), no definitive explanation exists for the apparent selective vulnerability (p”
Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages) (2002, background): “These inclusions present in the form of elongated and, in part,branching Lewy neurites (LNs) within cellular processes and as globular or spherical Lewy bodies (LBs) in the perikarya of involved neurons [3, 12, 15, 18, 20] (Fig.”
The clinical symptoms of Parkinson's disease (2016, background): “dopaminergic nigrostriatal neurons with Lewy bodies is regarded as the primary neuropathological correlate of motor impairment in Parkinson’s disease, but glutamatergic, cholinergic, GABA-ergic, tryptaminergic, noradrenergic and adrenergic nerve cells may show similar damage in their cytoskeleton (B”
Effects of coenzyme Q10 in early Parkinson disease: evidence of slowing of the functional decline. (2002, background): “The cardinal pathological features of PD are loss of dopaminergic neurons in the substantia nigra pars compacta and the presence of Lewy bodies in neurons in the substantia nigra and extranigral regions of the brain.(2,3) The causes of PD are not fully understood,(4) but genetic abnormalities and en”
Staging of brain pathology related to sporadic Parkinson's disease. (2003, background): “It is important to note that the somato-motor dysfunctions experienced by PD-patients—rather than solely reflecting a loss of dopaminergic neurons within the nigrostriatal system—may be traceable to extranigral impairment of the motor system [10,13].”
Idiopathic hyposmia as a preclinical sign of Parkinson's disease (2004, background): “PD-related pathological changes in the substantia nigra are always accompanied by extensive extranigral pathology.(16) According to a novel and provocative pathological staging system for PD by Braak and colleagues, the neuropathological process actually may start in extranigral structures, includin”
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen (2003, background): “…bodies that present in the form of spindle- or thread-like and, in part, arborizing LNs within neuronal processes and as globular or spherical LBs in the perikarya of nerve cells (Lewy, 1912; Gibb et al., 1991; Pollanen et al., 1993; Lowe, 1994; Braak et al., 1998; Braak and Braak, 2000; Fig.”