Staging of brain pathology related to sporadic Parkinson's disease.

By H. Braak, K. Del Tredici, Udo Rüb, R. D. de Vos, E. J. Jansen Steur, E. Braak. Neurobiology of Aging, 2003

10,043 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/c5295b755e550e50294bbadf52c9324ee5319d7b

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In Neurology

Citations in the corpus

Direct evidence of Parkinson pathology spread from the gastrointestinal tract to the brain in rats (2014, background): “In Braak’s observations, Lewy pathology first manifests in enteric neurons of the gut (stage 1) long before it is present in dopaminergic neurons of the midbrain and PD symptoms are evident (stage 3) [7].”
Identifying prodromal Parkinson's disease: Pre‐Motor disorders in Parkinson's disease (2012, background): “As noted above, Braak et al.(1) observed early occurrence of lesions in important autonomic centers in brainstem before characteristic changes in the SNpc.”
Pathogenic Protein Seeding in Alzheimer’s Disease and Other Neurodegenerative Disorders (2011, background): “In the brain, the a-synuclein–rich lesions that typify Lewy body disease/Parkinson disease first arise in the lower brainstem (notably the dorsal motor nucleus of the vagus nerve), and in the anterior olfactory nucleus and the olfactory bulb; they subsequently appear in a predictable sequence in mes”
DJ-1 and alpha-synuclein in human cerebrospinal fluid as biomarkers of Parkinson's disease. (2010, background): “Gene mutations of -synuclein lead to familial Parkinson’s disease and its protein product is intimately associated with the pathogenesis of Parkinson’s disease (familial or sporadic) (Lucking and Brice, 2000; Braak et al., 2003).”
Neurodegenerative disease and adult neurogenesis (2011, background): “Brain regions differ in their vulnerability to aging; some regions that are very sensitive to age-related neurodegenerative changes are the DG of the hippocampus, subiculum (Small, 2003) and OB (Braak et al., 2003).”
Gut microbiota are related to Parkinson's disease and clinical phenotype (2015, background): “Within the central nervous system (CNS), early alpha-synuclein pathology is often found in structures supplying parasympathetic innervation to the gut.(2,4) Thus, the vagal nerve could be a route for spreading of alpha-synuclein–related neuropathology from the ENS to the CNS.”
Selective neuronal vulnerability in Parkinson disease (2017, background): “a | A schematic representation of the spread of Lewy pathology (LP) within different brain structures, based on the study of Braak et al.(173), is shown.”
Differential Roles of M1 and M2 Microglia in Neurodegenerative Diseases (2015, background): “accumulation of protein aggregates called Lewy bodies (LBs) in the remaining DA neurons [65, 66] .”
Mitochondrial Dysfunction in Parkinson's Disease (2011, background): “LBs are also reported in cognitively intact individuals over 65 years [144] although this may indicate a prodromal phase of PD prior to clinical presentation.”