Staging of the intracerebral inclusion body pathology associated with idiopathic Parkinson's disease (preclinical and clinical stages)

By H. Braak, K. Del Tredici, H. Bratzke, John Hamm-Clement, D. Sandmann-Keil, Udo Rüb. Journal of Neurology, 2002

688 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/5ff190b28336f60a90e4740d583867e962bf3460

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Citations in the corpus

The parkinson's complex: Parkinsonism is just the tip of the iceberg (2006, background): “These investigators studied the brains of individuals who did not manifest parkinsonism in life, but did have Lewy body pathology, in addition to the brains of patients dying of PD in various stages, and concluded that the disease actually begins in the lower brainstem and olfactory bulb, and that o”
Unified Staging System for Lewy Body Disorders: Correlation with Nigrostriatal Degeneration, Cognitive Impairment and Motor Dysfunction (2009, background): “These two schemes have been differentially conceived, one for PD and the other for DLB [10, 12, 66, 67].”
The distinct cognitive syndromes of Parkinson's disease: 5 year follow-up of the CamPaIGN cohort. (2009, background): “Pathological changes in Parkinson’s disease occur in a predictable sequence, with Lewy body deposition in the nigrostriatal system during the early stages and pathological changes within the cortex occurring later (Braak et al., 2002).”
The energy cost of action potential propagation in dopamine neurons: clues to susceptibility in Parkinson's disease (2013, background): “Furthermore, it has been proposed that PD begins in the brain-stem and a wave of pathology progresses rostrally, when the midbrain is reached, SNc dopamine neurons degenerate and the major motor symptoms of PD ensue (Braak et al., 2002, 2004).”
Idiopathic Parkinson's disease: possible routes by which vulnerable neuronal types may be subject to neuroinvasion by an unknown pathogen (2003, background): “…of schematic diagrams, the existence of uninterrupted chains of vulnerable neuronal pathways that closely link the enteric nervous system with the central nervous system and the existence of neuronal pathways interconnecting all of the known predilection sites within the brain (Braak et al., 2003).”
α-Synuclein propagates from mouse brain to grafted dopaminergic neurons and seeds aggregation in cultured human cells. (2011, positive): “…that spreading of misfolded α -syn, followed by permissive templating of natively unfolded α -syn in the recipient cells, can account for α -syn pathology progressively affecting greater parts of the nervous system of PD patients in accordance with Braak neuropathological stages (13, 30).”