Idiopathic hyposmia as a preclinical sign of Parkinson's disease

By M. M. Ponsen, D. Stoffers, J. Booij, B. van Eck-Smit, E. Wolters, Henk W. Berendse. Annals of Neurology, 2004

799 citations recorded by the source corpus.

Subfields: Neurology, Nutrition and Dietetics, Sensory Systems

View Paper: https://www.semanticscholar.org/paper/001bbd2eb4ac234f87b906db3ff639243e53bfa8

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In Neurology

1. H. Ko
2. K. Del Tredici
3. Valina L. Dawson
4. T. Dawson
5. H. Braak
6. C. Hawkes
7. Lenore J. Launer
8. Dag Aarsland

Citations in the corpus

• Association of olfactory dysfunction with risk for future Parkinson's disease (2008, background): “Among the patients who underwent a second scan, mean decline in -CIT binding was greater in the hyposmic patients than in those who were normosmic.(6) A prospective study of World War II veteran twins tested olfactory identification in 19 unaffected brothers who had a twin with PD.”
• Transneuronal Propagation of Pathologic α-Synuclein from the Gut to the Brain Models Parkinson's Disease. (2019, background): “It is important to note that non-motor symptoms, such as hyposmia, disturbances in sleep, gastrointestinal dysfunction, and cognitive and emotional deficits, are common features of clinical PD along with the motor symptoms (Pfeiffer, 2003; Ponsen et al., 2004; Ressler and Mayberg, 2007).”
• Diagnosis and treatment of Parkinson disease: molecules to medicine. (2006, background): “Studies are being conducted to search for other possible diagnostic aids in PD, of which some of the most promising use transcranial ultrasound (33), examine deficits in olfaction (34), and determine oligomeric α-synuclein in blood from PD patients (35).”
• Identifying prodromal Parkinson's disease: Pre‐Motor disorders in Parkinson's disease (2012, background): “The prospective study by Ponsen et al.43 revealed that 40 of 78 relatives of PD patients were hyposmic at baseline and 4 of these developed PD after 2 years.”
• Parkinson's disease: a dual‐hit hypothesis (2007, background): “There were significant differences in sons and daughters, particularly where the affected parent was the father.This work has been criticized [45] because there may have been self-selection in allegedly unaffected relatives -who may have had undisclosed motor complaints resulting in the unusually hi”
• Olfactory disorders and quality of life--an updated review. (2014, background): “Olfactory impairment is an early sign of Alzheimer’s disease (Nordin 2012) and Parkinson’s disease (Ponsen et al. 2004), and poor QoL and depression are common in dementia (Hoe et al.”
• Epidemiology and etiology of Parkinson’s disease: a review of the evidence (2011, background): “tives with hyposmia had PD, versus none of 38 relatives without hyposmia [516].”