Role of Akt Signaling in Vascular Homeostasis and Angiogenesis

By I. Shiojima, K. Walsh. Circulation Research, 2002

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Perturbations of the AKT signaling pathway in human cancer (2005, background): “For example, VEGF exhibits multiple biological activities in endothelial cells, and VEGF effects on cell survival have been shown to be mediated by the Flk1/VEGFR2-PI3K-AKT pathway (reviewed in Shiojima and Walsh, 2002).”
The Vascular Endothelium and Human Diseases (2013, background): “Chronic and recurrent limb ischemia stimulates compensatory formation of collateral vessels (27-30), and this response depends on the bioavailabity of nitric oxide (31-33).”
mTOR and cancer: insights into a complex relationship (2006, background): “Given the important role of Akt in these processes (reviewed in Ref”
FoxOs are lineage-restricted redundant tumor suppressors and regulate endothelial cell homeostasis. (2007, positive): “In addition to a direct role in tumor development, PI3K-AKT signaling has been linked to endothelial cell (EC) homeostasis (Shiojima and Walsh, 2002).”
Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. (2007, positive): “In particular, we found transcripts associated with the PI3K/AKT signalling pathway and with eNOS, known to be involved in the angiogenic and anti-apoptotic program.(43,44) Interestingly, MVs carried also the gene POLR2B encoding the polymerase responsible for synthesizing mRNA in eukaryotes.”