Linear ubiquitination prevents inflammation and regulates immune signalling

By Björn Gerlach, Stefanie M. Cordier, Anna C. Schmukle, Christoph H. Emmerich, E. Rieser, T. Haas, A. Webb, J. Rickard, H. Anderton, W. Wong and 6 more. Nature, 2011

935 citations recorded by the source corpus.

Subfields: Cancer Research, Immunology, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8aee93ae455e6e0ca0b5cb7d046fc64db483ee6e

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Citations in the corpus

TNF and TNF-receptors: From mediators of cell death and inflammation to therapeutic giants - past, present and future. (2014, neutral): “[86–90].”
ZBP1 and TAK1: Master Regulators of NLRP3 Inflammasome/Pyroptosis, Apoptosis, and Necroptosis (PAN-optosis) (2019, background): “Furthermore, defects in TAK1associated cell survival signaling molecules also trigger similar multifaceted cell death pathways and promote inflammatory immune responses (Gerlach et al., 2011; Vince et al., 2012; Dondelinger et al., 2013, 2015; Lawlor et al., 2015; Moriwaki et al., 2015; Peltzer et a”
The Role of Tumor Necrosis Factor Alpha (TNF-α) in Autoimmune Disease and Current TNF-α Inhibitors in Therapeutics (2021, background): “This signaling pathway results in the activation of nuclear factor κB (NF-κB) and mitogen-activated protein kinases (MAPKs) [14,15].”
Targeting IAP proteins for therapeutic intervention in cancer (2012, background): “In coordination with haem-oxidized IRP2 ubiquitin ligase 1 (HOIL1; also known as RBCK1) and Sharpin, HOIP promotes the assembly of linear ubiquitin chains on NEMO and RIP1, and stabilizes the signalling complexe”
Deubiquitylating enzymes and drug discovery: emerging opportunities (2017, background): “Genetic loss of LUBAC components leads to immunodeficiency 174 and inflammatory phenotypes in mice [175] [176] [177] [178] , and mutations in LUBAC components also cause inflammatory conditions in humans 179, 180 .”
Crosstalk in NF-κB signaling pathways (2011, background): “In this context, K63 or linear ubiquitination of RIP1 may facilitate the recruitment and activation of IKK and TAK1 complexe”
Signaling in innate immunity and inflammation. (2012, background): “Underscoring the importance of sharpin in TNF signaling, mutation of Sharpin in mice causes chronic proliferative dermatitis that is rescued by TNF deficiency (Gerlach et al. 2011).”
Synchronized renal tubular cell death involves ferroptosis (2014, background): “This possibility has been ruled out in non-IRI settings by conditional tissue targeting of proteins involved in the prevention of spontaneously occurring necroptosis, such as RIPK1, and components that regulate its ubiquitinylation status [linear ubiquitinylation chain assembly complex (LUBAC), cell”
Regulation of tumour necrosis factor signalling: live or let die (2015, background): “Moreover, the absence of SHARPIN in cpdm mice increases cell death in the skin, and the cell death that occurs at this site resembles necroptosis 42 .”