Synchronized renal tubular cell death involves ferroptosis

By A. Linkermann, R. Skouta, N. Himmerkus, S. R. Mulay, Christin Dewitz, F. De Zen, Á. Prókai, G. Zuchtriegel, F. Krombach, P. Welz and 13 more. Proceedings of the National Academy of Sciences of the United States of America, 2014

1,038 citations recorded by the source corpus.

Subfields: Nutrition and Dietetics, Oncology, Pulmonary and Respiratory Medicine

View Paper: https://www.semanticscholar.org/paper/f9f46a5c2c0d9864247b136ac96f650566d248bc

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Nutrition and Dietetics

1. R. Kang
2. D. Tang
3. Scott J. Dixon
4. Brent R. Stockwell
5. M. Conrad
6. W. Yang
7. J. Cao
8. Guido Kroemer

In Oncology

1. Guido Kroemer
2. D. Tang
3. R. Kang
4. L. Galluzzi
5. Brent R. Stockwell
6. Scott J. Dixon
7. L. Zitvogel
8. M. V. Vander Heiden

In Pulmonary and Respiratory Medicine

1. Brent R. Stockwell
2. D. Tang
3. R. Kang
4. Guido Kroemer
5. M. Conrad
6. Xin Chen
7. Scott J. Dixon
8. Xuejun Jiang

Citations in the corpus

• Ferroptosis as a target for protection against cardiomyopathy (2019, background): “Ferroptosis has been implicated in the pathological process associated with carcinogenesis, degenerative diseases, stroke, and kidney ischemia/reperfusion (I/R) injury (5, 6).”
• The cell biology of ferroptosis (2024, neutral): “At a higher level of organization, understanding how contact and communication between two or more mammalian cells 32,197,198 and how molecules released by other organisms in the environment that act on mammalian cells 199,200 can regulate ferroptosis sensitivity will also be important for a full…”
• Emerging mechanisms and disease relevance of ferroptosis (2020, result): “features similar to those seen in patients [62,79].”
• Ferroptosis: Death by Lipid Peroxidation. (2016, background): “SRS16–86 is a third generation ferrostatin with increased plasma and metabolic stability; in an in vivo model of renal ischemia-reperfusion injury, SRS16–86 protected kidney function and extended mouse survival after ischemia-reperfusion injury [58].”
• Mechanisms of ferroptosis (2016, background): “ME beta-mercaptoethanol molecules, including Fer-1 [5], improved Fer-1 analogs [7, 8] and liproxstatin-1 [9], that potently and specifically block ferroptosis.”
• Necroptosis: Mechanisms and Relevance to Disease (2016, positive): “…and/or phosphorylation levels) are common to various renal disorders (at least in mice), including acute kidney injury (AKI) caused by I/R (115, 119, 162), urolithiasis (163), cisplatin-based chemotherapy or radiocontrast (115, 164–167), and chronic kidney disease after unilateral nephrectomy…”
• NOX4 promotes ferroptosis of astrocytes by oxidative stress-induced lipid peroxidation via the impairment of mitochondrial metabolism in Alzheimer's diseases (2021, background): “Ferroptosis-derived dead cells can release damage-associated molecular patterns (DAMPs) and lipid metabolites that can cause an elevation of inflammation [76,77].”