A role for the NAD-dependent deacetylase Sirt1 in the regulation of autophagy

By In Hye Lee, Liu Cao, R. Mostoslavsky, D. Lombard, Jie Liu, Nicholas E. Bruns, M. Tsokos, F. Alt, Toren Finkel. Proceedings of the National Academy of Sciences of the United States of America, 2008

1,458 citations recorded by the source corpus.

Subfields: Epidemiology, Geriatrics and Gerontology, Physiology

View Paper: https://www.semanticscholar.org/paper/8acceab9b09abfad80efb90b4ab5f2c2d7ac9fd1

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Citations in the corpus

The pros and cons of phytoestrogens (2010, positive): “This effect appears to be conferred by the upregulation of the Sir2 gene (mammalian homolog is SIRT 1, SIR2L1 or Sir2α), a member of the sirtuin family, long hypothesized to play a role in the lifespan-extending effects of caloric restriction [143].”
Autophagy and apoptosis dysfunction in neurodegenerative disorders. (2014, positive): “Sirt1 promotes autophagy by directly interacting with ATG5, ATG7 and LC3/ATG8 (Lee et al., 2008).”
Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, positive): “A transgenic mouse model of SCA3 showed low levels of sirtuin 1 (Cunha-Santos et al., 2016), an enzyme that normally deacetylates several autophagy proteins to promote autophagy (Huang et al., 2015; Lee et al., 2008).”
Histone Deacetylase Inhibitors as Anticancer Drugs (2017, background): “SIRT1 forms a complex with components of the autophagy machinery (Atg5, -7, and -8) and stimulates autophagy [78].”
Deacetylation of nuclear LC3 drives autophagy initiation under starvation. (2015, background): “Protein acetylation is known to play an important role in autophagy (Yi et al., 2012; Lee et al., 2008; Lee and Finkel, 2009; Lin et al., 2012; Füllgrabe et al., 2013; Morselli et al., 2010), and Atg8 (the yeast homolog of LC3) has been shown to be deacetylated in response to starvation (Lee et al.”
Mitochondria supply membranes for autophagosome biogenesis during starvation (2010, background): “…yeast Atg9p and Atg5 can localize to mitochondria (Reggiori et al., 2005; Takahashi et al., 2007b; Yousefi et al., 2006), and several mitochondrial proteins (e.g., smARF, Bif-1/EndophillinB, Sirt1) positively regulate autophagy (Lee et al., 2008; Reef et al., 2006; Takahashi et al., 2007a).”
Crosstalk between apoptosis, necrosis and autophagy. (2013, background): “Indeed, Sirt1 forms a complex with, and deacetylates several autophagy components, such as ATG5, ATG7 and ATG8, to induce autophagy [128].”
The hallmarks of aging. (2013, background): “SIRT1 modulates mitochondrial biogenesis through a process involving the transcriptional coactivator PGC-1a (Rodgers et al., 2005) and the removal of damagedmitochondria by autophagy (Lee et al., 2008).”
Mechanisms of Vascular Aging (2018, background): “function in the vasculature, controlling mitochondrial biogenesis, mtROS production, and cellular energy metabolism,(42,60,66) as well as removal of damaged mitochondria by autophagy.(67)”