Deacetylation of nuclear LC3 drives autophagy initiation under starvation.
By Rui Huang, Yinfeng Xu, W. Wan, Xin Shou, Jiali Qian, Zhiyuan You, Bo Liu, Chunmei Chang, Tianhua Zhou, Jennifer Lippincott-Schwartz and 1 more. Molecules and Cells, 2015
616 citations recorded by the source corpus.
Subfields: Cell Biology, Epidemiology, Geriatrics and Gerontology
View Paper: https://www.semanticscholar.org/paper/c08e66de5b6f27991abee2ef2f7f2a9c77c2a184
How researchers see this paper
The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.
In Cell Biology
In Epidemiology
- I. Slaninová
- T. Johansen
- T. Lamark
- Fiona M Menzies
- Angeleen Fleming
- D. Rubinsztein
- E. Seto
- N. Mizushima
In Geriatrics and Gerontology
Citations in the corpus
- Targeted protein degradation: mechanisms, strategies and application (2022, background): “Whereas AUTAC recruits autophagosomes for degradation, ATTEC binds to LC3, one of the key proteins of autophagosome.(98,99) Lu and coworkers discovered a set of small molecules that are capable binding of LC3 protein and pathogenic mutant huntingtin proteins.”
- HDACs and HDAC Inhibitors in Cancer Development and Therapy (2016, positive): “Sirt1 activity is necessary for the induction of starvation-induced autophagy by directly deacetylating critical regulators of the autophagy machinery, including Atg5, Atg7, Atg8, and LC3 (Lee et al. 2008; Huang et al. 2015a).”
- Autophagy mediates degradation of nuclear lamina (2015, positive): “Several mammalian autophagy proteins are present in the nucleus, including LC3 7,8 , Atg5 9 , and Atg7 10 .”
- Cellular mitophagy: Mechanism, roles in diseases and small molecule pharmacological regulation (2023, background): “Additionally, FUNDC1 is a mitochondrial outer membrane protein, which can induce Parkin-independent mitophagy in mammalian cells under hypoxia by interacting with LC3 [42].”
- Guidelines for the use and interpretation of assays for monitoring autophagy (3rd edition) (2012, positive): “One prominent ATG protein that is subjected to pro-autophagic deacetylation is LC3.(656,657)”
- Autophagy and Neurodegeneration: Pathogenic Mechanisms and Therapeutic Opportunities. (2017, positive): “A transgenic mouse model of SCA3 showed low levels of sirtuin 1 (Cunha-Santos et al., 2016), an enzyme that normally deacetylates several autophagy proteins to promote autophagy (Huang et al., 2015; Lee et al., 2008).”