Regional cerebral blood flow in the amygdala and medial prefrontal cortex during traumatic imagery in male and female Vietnam veterans with PTSD.

By Lisa M. Shin, Scott P. Orr, M. A. Carson, Scott L. Rauch, M. L. Macklin, N. Lasko, P. Peters, L. Metzger, D. Dougherty, Paul A. Cannistraro and 3 more. Archives of General Psychiatry, 2004

813 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Clinical Psychology, Cognitive Neuroscience

View Paper: https://www.semanticscholar.org/paper/8aaf814e63c5f5c029be3818335ab5e37d153c32

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Citations in the corpus

Repeated stress induces dendritic spine loss in the rat medial prefrontal cortex. (2006, background): “One potential neuroantomical substrate relevant to PTSD is the medial PFC-amygdala circuit (Newport and Nemeroff, 2000).”
Neurocircuitry models of posttraumatic stress disorder and extinction: human neuroimaging research--past, present, and future. (2006, methodology): “In a symptom provocation PET study, Shin et al (2004b) found that in the PTSD group, rCBF changes in medial frontal gyrus were significantly negatively correlated with rCBF changes in bilateral amygdala.”
Functional neuroimaging of anxiety: a meta-analysis of emotional processing in PTSD, social anxiety disorder, and specific phobia. (2007, background): “Of the studies for which this information was available, two studies of PTSD had complete overlap in subject cohorts (21, 22), and two pairs of studies had partial overlap (6, 7, 28, 29).”
The Neurocircuitry of Fear, Stress, and Anxiety Disorders (2011, background): “…and subcallosal cortex) during traumatic scriptdriven imagery (Bremner et al, 1999a; Britton et al, 2005; Lanius et al, 2001; Lindauer et al, 2004a; Shin et al, 1999, 2004a), the presentation of trauma-related stimuli (Bremner et al, 1999b; Hou et al, 2007; Yang et al, 2004), and negative,…”
A Review of Adversity, The Amygdala and the Hippocampus: A Consideration of Developmental Timing (2009, positive): “…events (e.g., combat, physical assault) and show that in adults the amygdala is both smaller (Driessen et al., 2000; Schmahl et al., 2003) and more reactive to emotional stimuli (Liberzon et al., 1999; Rauch et al., 2000; Shin et al., 2004; Armony et al., 2005; reviewed in Shin et al., 2006).”
The experience of emotion. (2007, background): “…disorder (e.g., Nakao et al. 2005, Valente et al. 2005), posttraumatic stress disorder (e.g., Bryant et al. 2005; Rauch et al. 2000; Shin et al. 2004, 2005), social anxiety and generalized anxiety disorder (for a review see Stein et al. 2002), and panic disorder (e.g., Kent et al.…”
Trauma modulates amygdala and medial prefrontal responses to consciously attended fear (2006, background): “, 2000), particularly for combat veterans (Shin et al., 2004).”
Extinction circuits for fear and addiction overlap in prefrontal cortex. (2009, background): “PTSD patients exhibit decreased activity within vmPFC when exposed to traumatic reminders (Bremner et al. 1999; Shin et al. 2004; Phan et al. 2006), suggesting that the vmPFC in humans is analogous to IL-mPFC in the rodent.”
Emotion and the motivational brain (2009, methodology): “…desensitization (e.g., Wolpe, 1961) and exposure (e.g., Foa and Kozak, 1986) have been important methods in the treatment of anxiety disorders, fMRI and PET studies of limbic circuits have focused almost exclusively on imagery activation during aversive emotional imagery (e.g., Shin et al., 2004).”
Biological substrates of emotional reactivity and regulation in adolescence during an emotional go-nogo task. (2008, background): “Functional magnetic resonance imaging studies have found greater amygdala activity in response to negatively valenced information (often fearful faces) and diminished activation of vPFC (16,33,34) in clinically anxious children and adults relative to control subjects.”
The diagnosis of mental disorders: the problem of reification. (2010, positive): “F or p er so na l u se o nl y. activation (Etkin & Wager 2007; Nitschke et al. 2009; Shin et al. 2004, 2005; Yehuda & LeDoux 2007).”
Emotion Modulation in PTSD: Clinical and Neurobiological Evidence for a Dissociative Subtype (2010, background): “These include PET studies showing a negative correlation between blood flow in the left ventromedial prefrontal cortex and the amygdala during emotional tasks (26), and negative correlations between medial prefrontal cortex and the amygdala during fear conditioning (25).”