Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and βAPP processing
By Gang Yu, M. Nishimura, S. Arawaka, D. Levitan, Lili Zhang, A. Tandon, You-Qiang Song, E. Rogaeva, Fusheng Chen, T. Kawarai and 20 more. Nature, 2000
966 citations recorded by the source corpus.
Subfields: Aging, Cell Biology, Physiology
View Paper: https://www.semanticscholar.org/paper/8a4ddf3c91fcf1674d3910f15c428ba33e17f5e0
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Citations in the corpus
- Pathological roles of MAPK signaling pathways in human diseases. (2010, background): “APP is an integral membrane protein that is cleaved sequentially by α-, β- (also termed BACE1), and γ-secretases to produce non-amyloidogenic or amyloidogenic Aβ proteins [21–23] (Fig.”
- Trafficking and proteolytic processing of APP. (2012, background): “Additional complex components are nicastrin (NCT), anterior pharynx defective (APH)-1a or APH-1b, and the PS enhancer (PEN)-2 (Yu et al. 2000; Francis et al. 2002).”
- APP processing and synaptic function. (2003, neutral): “…thus sought to develop a system where the physiologic effects of acute APP overexpression pear to influence A production (Sabo et al., 2001; Sastre et al., 1998; Yu et al., 2000), there is little informationcould be ascertained and in which the relevant molecu- lar determinants could be dissected.”
- aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation (2002, background): “…has beenPharmacia Corporation identified based on its physical association with preseni-Kalamazoo, Michigan 49007 lins and with the -secretase substrates Notch and APP, as well as by its functional requirement in Notch signaling (Yu et al., 2000; Goutte et al., 2000; Chen et Summary al., 2001).”