aph-1 and pen-2 Are Required for Notch Pathway Signaling, γ-Secretase Cleavage of βAPP, and Presenilin Protein Accumulation

By Ross Francis, G. Mcgrath, Jianhuan Zhang, D. Ruddy, M. Sym, Javier Apfeld, M. Nicoll, M. Maxwell, Bing Hai, M. C. Ellis and 10 more. 2002

740 citations recorded by the source corpus.

Subfields: Cellular and Molecular Neuroscience, Molecular Biology, Physiology

View Paper: https://www.semanticscholar.org/paper/4e9ea23b5e45e95b9dd0cb9b3d56b3411705a192

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cellular and Molecular Neuroscience

1. Christian Haass
2. Sangram S. Sisodia
3. M. Fortini
4. D. Holtzman
5. J. Long

In Molecular Biology

1. M. Fortini
2. Yue Hu
3. Christian Haass
4. F. LaFerla

In Physiology

1. Christian Haass
2. Sangram S. Sisodia
3. M. Fortini
4. Catherine Au
5. G. Thinakaran
6. C. Kaether
7. F. LaFerla
8. D. Holtzman

Citations in the corpus

• Textpresso: An Ontology-Based Information Retrieval and Extraction System for Biological Literature (2004, neutral): “…(see Table 5): the PMID:11994313 (Norman and Moerman 2002), PMID:12091304 (Alper and Kenyon 2002), PMID:12051826 (Maduzia et al. 2002), PMID:12110170 (Francis et al. 2002), PMID:12110172 (Bei et al. 2002), PMID:12065745 (Scott et al. 2002), PMID:12006612 (Piekny and Mains 2002), and…”
• Different cofactor activities in γ-secretase assembly (2003, background): “Th e Jo ur na l o f C el l B io lo gy JCB 685 Report The Journal of Cell Biology, Volume 161, Number 4, May 26, 2003 685–690 http://www.jcb.org/cgi/doi/10.1083/jcb.200304014”
• Caenorhabditis elegans: An Emerging Model in Biomedical and Environmental Toxicology (2008, background): “Studies on betaAPP transgenic worms revealed toxicity mechanisms of AD by identifying two new genes, aph-1 and pen-2, likely involved in the progression of the disease (Boyd-Kimball et al., 2006; Francis et al., 2002).”
• Reconsideration of Amyloid Hypothesis and Tau Hypothesis in Alzheimer's Disease (2018, background): “C83 and C99 are further cleaved at the γ-sites by γ-secretase complex, which includes presenilin-1, nicastrin, Aph-1 and Pen2 (Capell et al., 1998; De Strooper et al., 1998; Yu et al., 2000; Francis et al., 2002; Goutte et al., 2002; Takasugi et al., 2003).”
• Calcium dyshomeostasis and intracellular signalling in alzheimer's disease (2002, background): “cgi?l=23385">nicastrin , Aph1 (anterior pharynx defective) and Pen2 (presenilin enhancer), and others might remain to be identifie”
• APP processing in Alzheimer's disease (2011, neutral): “genetic screening of Caenorhabditis elegans [109,110].”