Development of definitive endoderm from embryonic stem cells in culture

By Atsushi Kubo, K. Shinozaki, J. Shannon, V. Kouskoff, M. Kennedy, S. Woo, H. Fehling, G. Keller. Development, 2004

893 citations recorded by the source corpus.

View Paper: https://www.semanticscholar.org/paper/8a11df923e4d0afb6bb063c55903e91227d5c83d

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Citations in the corpus

Gene function in mouse embryogenesis: get set for gastrulation (2007, background): “The requirement of high levels of nodal for formation of definitive endoderm is supported by the observation that endodermal marker genes are activated in mouse ES cells when high concentrations of a TGFB-related factor, activin A, are presen”
Differentiation of embryonic stem cells to clinically relevant populations: lessons from embryonic development. (2008, background): “addition of activin A (activin) induced a PS population and the subsequent formation of endoderm or mesoderm, depending on the strength of the signal (Kubo et al., 2004).”
Making a commitment: cell lineage allocation and axis patterning in the early mouse embryo (2009, background): “High doses of activin mimic nodal signalling and promote DE differentiatio”
Embryonic stem cell differentiation: emergence of a new era in biology and medicine. (2005, background): “While FCS appears to efficiently induce mesoderm populations, particularly the hematopoietic, vascular, and cardiac lineages, findings from a recent study demonstrate that it is not the optimal inducer of endoderm (Kubo et al. 2004).”
Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines. (2011, background): “During embryonic development, agonists and antagonists of these pathways establish signaling gradients across the embryo, resulting in the specification of appropriate germ layer populations and derivative tissues (Agius et al., 2000; Gadue et al., 2006; Gritsman et al., 2000; Kubo et al., 2004; Lad”
Efficient differentiation of human embryonic stem cells to definitive endoderm (2005, neutral): “In a recent study, mouse ES cells were differentiated to mesendoderm and subsequently to mesoderm and definitive endoderm by treatment with activi”
Tet1 and Tet2 regulate 5-hydroxymethylcytosine production and cell lineage specification in mouse embryonic stem cells (2011, background): “Downstream of Activin/Nodal receptors, moderate and strong inductive signals mediated by Smad2/3 support differentiation into mesoderm and definitive endoderm lineages marked by Brachyury and Foxa2 expression, respectively (Gadue et al., 2006; Kubo et al., 2004).”