Stage-specific optimization of activin/nodal and BMP signaling promotes cardiac differentiation of mouse and human pluripotent stem cell lines.

By Steven J. Kattman, A. Witty, Mark Gagliardi, N. Dubois, M. Niapour, A. Hotta, J. Ellis, G. Keller. Cell Stem Cell, 2011

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Dynamic and Coordinated Epigenetic Regulation of Developmental Transitions in the Cardiac Lineage (2012, neutral): “Directed differentiations and analyseswere performed essentially as described in (Kattman et al., 2011).”
Production of De Novo Cardiomyocytes: Human Pluripotent Stem Cell Differentiation and Direct Reprogramming (2012, positive): “As with cardiac development in vivo, it is now clear that inhibition of WNTaswell asBMPandTGFB/activin/NODALduring themiddifferentiation stage has a major role in hPSC cardiomyogenesis (Ren et al., 2011;Willems et al., 2011; Kattman et al., 2011; Zhang et al., 2011).”
Making muscle: skeletal myogenesis in vivo and in vitro (2017, background): “These studies identified BMP signaling as a key requirement for hematopoietic progenitor specification and they established the role of Wnt signaling for mesoderm induction in vitro (Chadwick et al., 2003; Gadue et al., 2006; Johansson and Wiles, 1995; Kattman et al., 2011; Lindsley et al., 2006; Na”
Redefining the in vivo origin of metanephric nephron progenitors enables generation of complex kidney structures from pluripotent stem cells. (2014, background): “Finally, the protocol established by these strategies was successfully applied to the induction of metanephric nephron progenitors from mouse embryonic stem cells (ESCs) and human induced pluripotent stem cells (iPSCs), thereby advocating a model for kidney lineage specification.”