IL-7 is critical for homeostatic proliferation and survival of naïve T cells

By Joyce T. Tan, Eric P. Dudl, E. Leroy, R. Murray, J. Sprent, K. Weinberg, C. Surh. Proceedings of the National Academy of Sciences of the United States of America, 2001

1,100 citations recorded by the source corpus.

Subfields: Immunology, Oncology

View Paper: https://www.semanticscholar.org/paper/89e1c2965c35df7dfcceca8be1076cab38cd77bb

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Immunology

1. C. Surh
2. M. Bevan
3. J. Sprent
4. K. Schluns
5. D. Mathis
6. T. Fry
7. Nancie J. MacIver
8. Ryan D. Michalek

In Oncology

1. T. Fry
2. M. Bevan

Citations in the corpus

• Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells (2002, background): “Interestingly, however, in experiments in which cytokines were provided exogenously, IL-15, IL-4, and IL-12, were shown to enhance homeostatic proliferation of naive T cells (19, 31).”
• Vaccines: Effector and memory T-cell differentiation: implications for vaccine development (2002, neutral): “Soon after, CD8 + T-cell division commences at a rapid rate (∼6–8 hours per cell division), whereas CD4 + T-cell division is typically delayed for another 12–24 hours (36–48 hours after the initial stimulus) and then occurs at a slightly slower rate (∼10 hours per cell division”
• New insights into the regulation of T cells by γc family cytokines (2009, neutral): “Second, IL-7 induces the proliferation of naive and memory T cells in lymphopaenic conditions and of memory T cells, but not naive T cells, under normal physiological conditions”
• Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. (2014, background): “Furthermore, IL-7 drives the homeostatic expansion of naı̈ve T cells andcontributes inmaintaining thepoolof central-memoryTcells.(35,36) The molecular signature we performed on CAR-T cells expanded either in IL-2 or IL-7 and IL-15 by day 14 of culture, also shows differences in their gene expression”
• Cytokine control of memory T-cell development and survival (2003, background): “Antiviral CD8 + T-cell clonal expansion also does not require IL-7, but IL-7 is indispensable for the homeostatic expansion of naive CD4 + and CD8 + T cells in immunodeficient host”
• Metabolic Regulation of T Lymphocytes (2013, background): “IL-7 is essential for naive T cell survival (13), and induction of Bcl-2, in particular, plays an important role.”