Cytokine Requirements for Acute and Basal Homeostatic Proliferation of Naive and Memory CD8+ T Cells

By Ananda W. Goldrath, P. Sivakumar, M. Glaccum, M. Kennedy, M. Bevan, C. Benoist, D. Mathis, E. Butz. Journal of Experimental Medicine, 2002

693 citations recorded by the source corpus.

Both naive and memory T cells undergo antigen-independent proliferation after transfer into a T cell–depleted environment (acute homeostatic proliferation), whereas only memory T cells slowly divide in a full T cell compartment (basal proliferation). We show, first, that naive and memory CD8+ T cells have different cytokine requirements for acute homeostatic proliferation. Interleukin (IL)-7 receptor(R)α–mediated signals were obligatory for proliferation of naive T cells in lymphopenic hosts, whereas IL-15 did not influence their division. Memory T cells, on the other hand, could use either IL-7Rα– or IL-15–mediated signals for acute homeostatic proliferation: their proliferation was delayed when either IL-7Rα was blocked or IL-15 removed, but only when both signals were absent was proliferation ablated. Second, the cytokine requirements for basal and acute homeostatic proliferation of CD8+ memory T cells differ, as basal division of memory T cells was blocked completely in IL-15–deficient hosts. These data suggest a possible mechanism for the dearth of memory CD8+ T cells in IL-15– and IL-15Rα–deficient mice is their impaired basal proliferation. Our results show that naive and memory T lymphocytes differ in their cytokine dependence for acute homeostatic proliferation and that memory T lymphocytes have distinct requirements for proliferation in full versus empty compartments.

Subfields: Immunology

View Paper: https://www.semanticscholar.org/paper/35b4cc52436532de06b68aeb2adb1ddf4ea21729

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In Immunology

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Citations in the corpus

• New insights into the regulation of T cells by γc family cytokines (2009, neutral): “IL-7 seems to be the most important of the γ c family cytokines for regulating the homeostasis of naive and memory T cell”
• Shaping and reshaping CD8+ T-cell memory (2008, background): “Although the numbers of memory CD8 + T cells are stable, maintenance of memory CD8 + T-cell numbers after acute infection or vaccination is a dynamic process that involves cytokine-driven proliferation that is balanced by cell death (a process known as memory turnover”
• Effector and memory CD8+ T cell fate coupled by T-bet and eomesodermin (2005, background): “Two hallmarks of memory CD8 + T cells are their capacity for rapid recall of effector function when re-encountering a pathogen and their ability to undergo IL-15-driven proliferative renewal in the absence of pathogen attac”
• Cytokine control of memory T-cell development and survival (2003, background): “Three groups have shown that IL-15 is involved in the maintenance of antigen-specific memory CD8 + T cell”