Isl1 identifies a cardiac progenitor population that proliferates prior to differentiation and contributes a majority of cells to the heart.

By Chen-Leng Cai, Xingqun Liang, Yunqing Shi, Po-Hsien Chu, S. Pfaff, Ju Chen, S. Evans. Developmental Cell, 2003

1,689 citations recorded by the source corpus.

Subfields: Epidemiology, Molecular Biology, Surgery

View Paper: https://www.semanticscholar.org/paper/89c839c2fc0390157b9ced47765c113cc5ad2c7f

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In Epidemiology

1. Deepak Srivastava
2. C. Burns
3. R. Roberts
4. Ashley N. Coon
5. E. Olson
6. Kazu Kikuchi
7. Alexandra Lepilina
8. Jennifer E. Holdway

In Molecular Biology

1. Deepak Srivastava
2. E. Olson
3. Matthew J. Potthoff
4. Margaret E. Buckingham
5. J. Bakkers
6. Michael A. Rudnicki
7. Eva van Rooij
8. B. Bruneau

In Surgery

1. C. Burns
2. R. Roberts
3. Ashley N. Coon
4. Kazu Kikuchi
5. Alexandra Lepilina
6. Jennifer E. Holdway
7. K. Poss

Citations in the corpus

• MEF2: a central regulator of diverse developmental programs (2007, background): “, 2004); and a second enhancer that serves as a direct target of GATA4 and the LIM-homeodomain transcription factor ISL1, which is itself required for the formation of the anterior heart field (Dodou et al., 2004; Cai et al., 2003).”
• A dynamic epicardial injury response supports progenitor cell activity during zebrafish heart regeneration. (2006, positive): “Recent attempts to identify cardiac progenitor cells have revealedatleastthreerarecellpopulationswiththepotential to generate new cardiomyocytes (CMs) postnatally (Beltrami et al., 2003; Cai et al., 2003; Oh et al., 2003, Laugwitz et al., 2005).”
• Making or breaking the heart: from lineage determination to morphogenesis. (2006, background): “Upon rightward looping of the heart tube, SHF cells cross the pharyngeal mesoderm into the anterior and posterior portions, populating a large portion of the outflow tract, future right ventricle, and atria (Cai et al., 2003).”
• Multipotent embryonic isl1+ progenitor cells lead to cardiac, smooth muscle, and endothelial cell diversification. (2006, positive): “Although indications exist that some cells of the endocardium originate from the second heart field progenitors ( Cai et al., 2003; Verzi et al., 2005), our results represent the first evidence that vascular endothelium arises from isl1+ precursors.”
• Building the mammalian heart from two sources of myocardial cells (2005, background): “fcgi?db=gene&cmd=Retrieve&dopt=full_report&list_uids=16392"> Isl1 (insulin gene enhancer protein, a LIM homeodomain transcription factor) expression in cells that are present in the murine anterior heart field, and that also extend more posteriorl”
• Zebrafish as a model to study cardiac development and human cardiac disease (2011, background): “Zebrafish isl1 is expressed in the lateral-most cells of the cardiac field.(15) Mouse and zebrafish”