Astrocyte-derived VEGF-A drives blood-brain barrier disruption in CNS inflammatory disease.

By A. Argaw, L. Asp, Jingya Zhang, K. Navrazhina, T. Pham, J. Mariani, S. Mahase, Dipankar J. Dutta, J. Seto, Elisabeth G. Kramer and 3 more. Journal of Clinical Investigation, 2012

655 citations recorded by the source corpus.

Subfields: Immunology and Allergy, Neurology

View Paper: https://www.semanticscholar.org/paper/3fb511a0b1261493b70971dfcc6b5c3c77643800

How researchers see this paper

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In Immunology and Allergy

1. A. Prat
2. R. Daneman

In Neurology

1. M. Sofroniew
2. M. Pekny
3. M. Pekna
4. J. Burda
5. F. Quintana
6. Alexander M. Bernstein
7. C. Farina
8. E. Colombo

Citations in the corpus

• Neuroinflammatory mechanisms of blood-brain barrier damage in ischemic stroke. (2019, background): “This is followed by reductions in claudin-5 and occludin expression in endothelial cells, BBB breakdown, and immune cell infiltration both in vitro and in vivo (4, 5, 168).”
• Astrocytes: Key Regulators of Neuroinflammation. (2016, background): “In fact mice with selective ablation of VEGF in GFAP-positive cells develop a milder EAE course associated with limited astrogliosis, BBB damage, immune cell infiltration and demyelination than wt mice [86] (Table 2 and Figure 1).”
• Astrocyte reactivity and reactive astrogliosis: costs and benefits. (2014, background): “VEGF secretion by reactive astrocytes can serve as a good example of a context-dependent response: the positive, stimulatory effect of VEGF on the formation of vessels and synapses in ischemic stroke (20, 263) contrasts with its induction of blood-brain barrier breakdown and lymphocyte infiltration ”
• The blood-brain barrier. (2015, background): “Although VEGF is a factor mostly known to promote angiogenesis during development, in adulthood, VEGF decreases the stability of the BBB during inflammatory conditions (Argaw et al. 2009, 2012).”
• Astrocyte roles in traumatic brain injury (2015, background): “For example, in response to stimulation by the pro-inflammatory cytokine IL-β, astrocytes generate and release vasoactive endothelial growth factor (VEGF) that increases blood-brain barrier permeability and promotes leukocyte extravasation (Argaw et al., 2009; Argaw et al., 2012).”
• Astrocyte crosstalk in CNS inflammation (2020, result): “In line with these findings, conditional ablation of Vegfa in astrocytes ameliorates EAE, and is characterized by a reduction in leukocyte infiltration, demyelination, and oligodendrocyte loss (Argaw et al., 2012).”