A blood–brain barrier overview on structure, function, impairment, and biomarkers of integrity

By Hossam Kadry, Behnam Noorani, L. Cucullo. Fluids and Barriers of the CNS, 2020

1,509 citations recorded by the source corpus.

The blood–brain barrier is playing a critical role in controlling the influx and efflux of biological substances essential for the brain’s metabolic activity as well as neuronal function. Thus, the functional and structural integrity of the BBB is pivotal to maintain the homeostasis of the brain microenvironment. The different cells and structures contributing to developing this barrier are summarized along with the different functions that BBB plays at the brain–blood interface. We also explained the role of shear stress in maintaining BBB integrity. Furthermore, we elaborated on the clinical aspects that correlate between BBB disruption and different neurological and pathological conditions. Finally, we discussed several biomarkers that can help to assess the BBB permeability and integrity in-vitro or in-vivo and briefly explain their advantages and disadvantages.

Subfields: Molecular Biology, Neurology, Oncology

View Paper: https://www.semanticscholar.org/paper/36a27341d24a86908854c4849682440254747d34

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1. Adelina-Gabriela Niculescu
2. Crina Ioana Radu
3. B. Costachescu
4. D. Teleanu
5. R. Teleanu
6. O. Vladâcenco
7. I. Lungu
8. A. Grumezescu

Citations in the corpus

• An Overview of Oxidative Stress, Neuroinflammation, and Neurodegenerative Diseases (2022, background): “Because the therapeutic agents need to reach the central nervous system (CNS), it is necessary to tailor appropriate vectors that can surpass the brain–blood barrier (BBB) [3,6].”