Chronic gastrointestinal inflammation induces anxiety-like behavior and alters central nervous system biochemistry in mice.

By P. Bercik, E. Verdú, J. Foster, J. Macri, M. Potter, X. Huang, Paul M. Malinowski, W. Jackson, P. Blennerhassett, Karen A Neufeld and 6 more. Gastroenterology, 2010

650 citations recorded by the source corpus.

Subfields: Behavioral Neuroscience, Biological Psychiatry, Molecular Biology

View Paper: https://www.semanticscholar.org/paper/8988ff2a21a58e088de5fb39f83d1254f54cb17d

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Behavioral Neuroscience

1. J. Cryan
2. Ted G. Dinan
3. Yan Wang
4. Emeran A. Mayer
5. L. Kasper
6. G. Clarke
7. S. Mazmanian

In Biological Psychiatry

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. P. Kennedy
5. S. Mazmanian
6. R. Stilling
7. Yan Wang
8. L. Kasper

In Molecular Biology

1. J. Cryan
2. Ted G. Dinan
3. G. Clarke
4. S. Mazmanian
5. Yan Wang
6. L. Kasper
7. P. Kennedy
8. R. Stilling

Citations in the corpus

• Gut Microbes and the Brain: Paradigm Shift in Neuroscience (2014, background): “rhamnosus strain, normalized infection-induced anxiety-like behavior (Bercik et al., 2010).”
• Kynurenine pathway metabolism and the microbiota‐gut‐brain axis (2017, background): “More subtle microbiota manipulations such as deliberate infection with Trichuris muris , also increases the kynurenine/tryptophan ratio (Bercik et al., 2010).”
• Intestinal microbiota in functional bowel disorders: a Rome foundation report (2012, background): “The interplay may be bidirectional as suggested by animal studies showing that the microbiota can affect brain chemistry and behaviour.(156) Nonetheless, for the time, the potential relevance of brainemicrobiota interactions have yet to be shown in humans in general and in FBD in particular.”
• The role of microbiome in central nervous system disorders (2013, positive): “Probiotic treatment with certain strains of B. longum, B. infantis, L. helveticus, or L. rhamnosus, either alone or in combination, normalized behavioral phenotypes in animal anxiety models (Bercik et al., 2010; Bravo et al., 2011; McKernan et al., 2010; Messaoudi et al., 2011; Ohland et al., 2013).”
• Ingestion of Lactobacillus strain regulates emotional behavior and central GABA receptor expression in a mouse via the vagus nerve (2011, methodology): “rhamnosus (JB-1) treatment was not significant [F(1, 62) = 1.”