Establishment and Maintenance of a Heterochromatin Domain

By Ira M. Hall, G. D. Shankaranarayana, K. Noma, N. Ayoub, A. Cohen, S. Grewal. Science, 2002

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The small RNA profile during Drosophila melanogaster development. (2003, neutral): “77, 143.chromatin (Hall et al., 2002; Volpe et al., 2002).”
The diverse functions of histone lysine methylation (2005, background): “The first break-through in this area came with the discovery that the RNA interference (RNAi) pathway has a role in heterochromatin formation in fission yeast 40,41 .”
Perspective: machines for RNAi. (2005, background): “In Caenorhabditis elegans and fungi like Neurospora crassa and Schizosaccharomyces pombe, genes encoding RdRP enzymes are required for silencing (Cogoni and Macino 1999; Dalmay et al. 2000; Mourrain et al. 2000; Smardon et al. 2000; Sijen et al. 2001; Hall et al. 2002; Volpe et al. 2002).”
RNA meets chromatin. (2005, background): “Underscoring another fundamental mechanism, a role for RNA in the establishment of heterochromatin formation has been uncovered from a series of elegant studies in fission yeast (Hall et al. 2002; Volpe et al. 2002) and plants (for review, see Gendrel and Colot 2005).”
The rise of regulatory RNA (2014, background): “…74,250 , fungi 251 and human cells 88 , with an intimate involvement of small RNAs and the RNA interference pathway in the epigenetic processes involved 251–253 , consistent with the observation that small RNAs interact with Polycomb 254 and that Ago proteins occur in the nucleus 86,87 (Figure 3).”