TLR9-dependent recognition of MCMV by IPC and DC generates coordinated cytokine responses that activate antiviral NK cell function.

By A. Krug, A. French, W. Barchet, Jens A. A. Fischer, A. Dzionek, J. Pingel, M. Orihuela, Shizuo Akira, W. Yokoyama, M. Colonna. Immunity, 2004

811 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology

View Paper: https://www.semanticscholar.org/paper/893ca0ec26550175594764426022b1bbed3a4d86

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In Epidemiology

1. Shizuo Akira
2. R. Medzhitov
3. K. Takeda
4. Satoshi Uematsu
5. Daniel B. Stetson
6. Yong‐jun Liu
7. S. Ghosh
8. M. Gilliet

In Immunology

1. Shizuo Akira
2. R. Medzhitov
3. S. Ghosh
4. Daniel B. Stetson
5. Taro Kawai
6. M. Hayden
7. Satoshi Uematsu
8. K. Takeda

Citations in the corpus

• NK cell development, homeostasis and function: parallels with CD8+ T cells (2011, background): “The early nonspecific NK cell response against MCMV, characterized by the secretion of IFNγ and TNF, but not IL-2, is also dependent primarily on the IL-12 and type I IFNs produced by conventional DCs (cDCs”
• Plasmacytoid dendritic cells prime IL-10–producing T regulatory cells by inducible costimulator ligand (2007, background): “There is indisputable evidence that pDCs can drive protective antiviral infl ammation through their ability to produce type 1 IFNs, which promotes the function of bystander mDCs (46–48), B cells (49), T cells (50), and NK cells (51, 52).”
• Toll-like receptor 7 and TLR9 dictate autoantibody specificity and have opposing inflammatory and regulatory roles in a murine model of lupus. (2006, background): “By identifying pDCs as CD11cint pDCA-1+ cells ( Krug et al., 2004 ), we found that splenic pDCs from Tlr92/2 mice ap-”
• Dendritic cells prime natural killer cells by trans-presenting interleukin 15. (2007, background): “Specifically, the limited role of DCderived IL-12 for IFN-g production in vivo was unexpected, but the majority of data indicating a nonredundant role of IL-12 for IFN-g production by NK cells were obtained from in vitro experiments (Andoniou et al., 2005; Ferlazzo et al., 2004; Krug et al., 2004).”
• Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions. (2005, positive): “HSV-1 (25, 26), HSV-2, and DNA purified from HSV-2 (27), as well as murine CMV (28) activate murine pDCs through TLR9.”