Endocytosis of HIV-1 activates plasmacytoid dendritic cells via Toll-like receptor-viral RNA interactions.

By A. Beignon, K. McKenna, M. Škoberne, O. Manches, I. Dasilva, D. Kavanagh, M. Larsson, R. Gorelick, J. Lifson, N. Bhardwaj. Journal of Clinical Investigation, 2005

716 citations recorded by the source corpus.

Subfields: Epidemiology, Immunology, Virology

View Paper: https://www.semanticscholar.org/paper/6a9b45c98b1558abed76bd87b51f79fc37eb213b

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Citations in the corpus

The immune response during acute HIV-1 infection: clues for vaccine development (2009, background): “In vitro , pDCs become activated by the binding of viral envelope proteins to CD4 expressed by the pDCs followed by virion endocytosis and by the triggering of Toll-like receptor 7 by viral RN”
Microbial translocation is a cause of systemic immune activation in chronic HIV infection (2006, background): “Clearly, HIV itself is a candidate for an innate immunostimulatory agent in infected individuals, as its RNA genome can stimulate pDCs in vitro through TLR7 (ref”
Induction of a Striking Systemic Cytokine Cascade prior to Peak Viremia in Acute Human Immunodeficiency Virus Type 1 Infection, in Contrast to More Modest and Delayed Responses in Acute Hepatitis B and C Virus Infections (2009, background): “Plasmacytoid DCs (pDCs), which act as the principal source of systemic IFN- production in many viral infections, are activated to produce cytokines following the endocytosis of HIV virions in vitro (4) and may have been triggered by systemic viral spread to produce the early elevations in plasma IFN”
Toll‐like receptors control autophagy (2008, background): “Consistent with this reactivity pattern, we found that a marker of autophagy was induced in a TLR8-dependent manner when HeLa cells were infected with HIV, a known source of naturally occurring GU-rich ssRNA (Heil et al, 2004; Beignon et al, 2005; Schlaepfer et al, 2006; Meier et al, 2007).”
Therapeutic potential of Toll-like receptor 9 activation (2006, background): “In contrast to original expectations, S-class ODN are not specific TLR9 inhibitors; some also block TLR7 and/or TLR8 and RNA-mediated immune activation, depending on the presence or absence of specific sequence motif”
Sexual Dimorphism in Innate Immunity (2019, neutral): “Interestingly, the expression of TLR7 in pDCs plays a central role in the activation of the immune system during infection by single-stranded RNA viruses, such as HIV-1, and the elevated expression of IFN-α by pDCs was considered as a major prognostic indicator for the clinical progression [69].”
Sex differences in the TLR-mediated response of pDCs to HIV-1 are associated with higher immune activation in infected women (2009, background): “pDCs have a central role in this HIV-1–induced activation of the immune system, as they can sense HIV-1 single-stranded RNA via TLR7 (refs”