Splanchnic lipolysis in human obesity.

By S. Nielsen, Zengkui Guo, C. M. Johnson, D. Hensrud, M. Jensen. Journal of Clinical Investigation, 2004

927 citations recorded by the source corpus.

Subfields: Cell Biology, Physiology, Surgery

View Paper: https://www.semanticscholar.org/paper/88ea2535e59ffd0143c694dcb4bfc8c08dbdfb64

How researchers see this paper

The researchers whose trusted networks rank it highest, strongest advocate first. Every researcher gets a different order.

In Cell Biology

1. P. Scherer
2. M. Trujillo
3. Gerald I. Shulman
4. S. Friedman
5. P. Seale

In Physiology

1. Gerald I. Shulman
2. J. Kirkland
3. T. Tchkonia
4. J. Despres
5. P. Scherer
6. M. Trujillo
7. P. Seale
8. André Tchernof

In Surgery

1. Martin Adiels
2. S. Olofsson
3. André Tchernof
4. J. Despres
5. Marja-Riitta Taskinen
6. P. Scherer
7. Gerald I. Shulman
8. S. Friedman

Citations in the corpus

• Sarcopenia, intramuscular fat deposition, and visceral adiposity independently predict the outcomes of hepatocellular carcinoma. (2015, background): “In addition, excess visceral fat leads to impaired suppression of FFA release in response to insulin [38].”
• Adipose Tissue Heterogeneity: Implication of depot differences in adipose tissue for Obesity Complications (2012, background): “3.2.1.3 In vivo analysis: Jensen’s group evaluated the relative contributions of viscerally derived FFA to the portal and systemic circulation in humans (Nielsen et al. 2004).”
• Overproduction of large VLDL particles is driven by increased liver fat content in man (2006, background): “Intra-abdominal fat is considered the major source of hepatic NEFA released directly into the portal vein [12].”
• Intrahepatic fat, not visceral fat, is linked with metabolic complications of obesity (2009, background): “In fact, only 20% of portal vein FFA delivered to the liver and 14% of systemic FFA delivered to skeletal muscle are derived from lipolysis of VAT in obese subjects (20, 21).”
• Adipose tissue plasticity in health and disease (2022, background): “However, this version of the portal hypothesis has fallen out of favor because studies in humans show that, while the proportion of portal vein and circulating FFAs from visceral fat increase in obesity (from 5% to 20% and from 6% to 14%, respectively), the visceral-fat-derived FFAs still represent ”
• Pathophysiology of human visceral obesity: an update. (2013, background): “Accordingly, in vivo experiments demonstrated that while visceral adipose tissue lipolysis accounts for a small proportion of whole body nonesterified fatty acid release, the contribution of this depot may be particularly apparent in the nocturnal phase (258) and increases up to 50% along with visce”
• Sex and Gender Differences in Risk, Pathophysiology and Complications of Type 2 Diabetes Mellitus (2016, background): “More recently, GLP-1 response was evaluated in a large cohort of subjects of both sexes, with different degrees of BMI and ranging from NGT to T2DM.”